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Merck
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文件

C5269

Sigma-Aldrich

克林霉素 盐酸盐

lincosamide antibiotic

别名:

克林霉素, （7S）-7-氯-7-脱氧林可霉素 盐酸盐

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About This Item

经验公式（希尔记法）:
C18H33ClN2O5S · HCl
CAS号:
21462-39-5
分子量:
461.44
Beilstein:
4070786
MDL號碼:
MFCD07793327
分類程式碼代碼:
51102829
PubChem物質ID:
24892772
NACRES:
NA.85

形狀

powder or crystals

雜質

≤13%

溶解度

H2O: 50 mg/mL

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1

InChI 密鑰

AUODDLQVRAJAJM-XJQDNNTCSA-N

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相关类别

一般說明

化学结构：大环内酯

應用

克林霉素用于研究细菌感染，例如 B 组链球菌病、细菌抗性和血浆蛋白结合。
用于研究细菌蛋白质合成。

生化／生理作用

克林霉素是一种由林可霉素制备的半合成林可酰胺类抗生素。 它通过与 50S 核糖体亚基的 23S rRNA 组分的氢键相互作用，抑制细菌蛋白质合成，从而诱导肽基-t-RNA 复合物的解离。它具有抗革兰氏阳性球菌的抗菌活性，以及抗弓形虫的抗原虫活性。
克林霉素盐酸盐对厌氧菌非常有效。

其他說明

林可酰胺类的抗菌和抗原生动物抗生素。
保持容器密闭，置于干燥通风处。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317,H319,H362

危險分類

Eye Irrit. 2 - Lact. - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Anouk E Muller et al.
Antimicrobial agents and chemotherapy, 54(5), 2175-2181 (2010-02-24)
The study presented here was performed to determine the pharmacokinetics of intravenously administered clindamycin in pregnant women. Seven pregnant women treated with clindamycin were recruited. Maternal blood and arterial and venous umbilical cord blood samples were obtained. Maternal clindamycin concentrations
J Spízek et al.
Applied microbiology and biotechnology, 64(4), 455-464 (2004-02-06)
Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria. They may even be bactericidal at the higher concentrations that can be reached in vivo. Clindamycin is usually more
Nasim Farahmand et al.
Microorganisms, 9(8) (2021-08-28)
A selection of 36 commercial probiotic fermented dairy products from UK and Europe markets were evaluated for the numbers, types, and viability of Lactobacillus strains against the stated information on their packages. A comparative study was carried out on selectivity
A Burian et al.
The Journal of antimicrobial chemotherapy, 66(1), 134-137 (2010-11-04)
although plasma protein binding (PPB) is accepted to be an essential factor in reducing antimicrobial activity, little is known about the underlying mechanisms. One possibility includes impaired penetration of an antimicrobial into bacterial cells in the presence of PPB. As
Sonja Löfmark et al.
The Journal of antimicrobial chemotherapy, 58(6), 1160-1167 (2006-10-19)
The aim was to study the long-term consequences of 1 week clindamycin administration regarding selection and persistence of resistance, resistance determinants and diversity of the Bacteroides spp. in the intestinal microflora. A total of 1306 Bacteroides isolates were collected from
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