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Merck

C2776

Sigma-Aldrich

1-氰基-4-二甲氨基吡啶四氟硼酸酯

organic cyanylating reagent

别名:

氰基吡啶试剂, CDAP

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About This Item

经验公式(希尔记法):
C8H10BF4N3
CAS号:
分子量:
234.99
Beilstein:
5685616
MDL號碼:
分類程式碼代碼:
12352108
PubChem物質ID:
NACRES:
NA.32

品質等級

形狀

powder

儲存溫度

−20°C

SMILES 字串

[F-].FB(F)F.CN(C)c1cc[n+](cc1)C#N

InChI

1S/C8H10N3.BF3.FH/c1-10(2)8-3-5-11(7-9)6-4-8;2-1(3)4;/h3-6H,1-2H3;;1H/q+1;;/p-1

InChI 密鑰

ONCRRSYBEJHQMM-UHFFFAOYSA-M

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一般說明

1-氰基-4-二甲氨基吡啶四氟硼酸酯是一种有机氰化剂,也称为CDAP。 基于其在酸性条件下的反应性,它是一种独特的胱氨酸标记试剂。这一特性使CDAP相较于其他巯基标记剂更具优势,因为它可避免可能的巯基-二巯基交换反应。

應用

1-氰基-4-二甲氨基吡啶四氟硼酸酯(CDAP)已作为一种氰化剂用于合成结合疫苗。用于免疫传感器的纤维素透析膜的激活使用CDAP作为激活剂。

特點和優勢

与类似试剂溴化氰(CNBr)相比,CDAP:

  • 更易于使用。
  • 可以在较低pH值下工作。
  • 副作用更少。
  • 溴化氰本身是一种有害物质。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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A Holmberg et al.
Bioconjugate chemistry, 4(6), 570-573 (1993-11-01)
This study presents a carrier system for boron, potentially useful in boron neutron capture therapy (BNCT). Na2B12H11SH (BSH) was covalently coupled to dextran derivatives. This was accomplished in two ways. The first method comprises activation of dextran with 1-cyano-4-(dimethylamino)pyridine (CDAP)
L J Shore et al.
The Journal of biological chemistry, 272(19), 12536-12543 (1997-05-09)
Ornithine decarboxylase (ODC) is the key initial enzyme in the biosynthesis of polyamines. Since polyamines have been shown to enhance protein kinase CK2 activity in vitro, ODC was overexpressed to examine the role of polyamines in CK2 regulation in vivo.
S Bystrický et al.
Glycoconjugate journal, 17(10), 677-680 (2001-06-27)
The possibility of using 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) for activation of saccharide hydroxyl groups (instead of hazardous cyanogen bromide) is examined with cell-surface mannans of the yeasts Candida albicans, Candida tropicalis, Candida lambica and galactoglucoxylomannan of Cryptococcus laurentii. Direct conjugation with
E Konadu et al.
Infection and immunity, 64(7), 2709-2715 (1996-07-01)
Salmonella paratyphi A, the second most common cause of enteric fever in Southeast Asia, is a habitant of and a pathogen for humans only. Lipopolysaccharides (LPS) are both essential virulence factors and protective antigens for systemic infections caused by groups
J Qi et al.
Biochemistry, 40(15), 4531-4538 (2001-04-11)
The disulfide structure of sillucin, a highly knotted, cysteine-rich, antimicrobial peptide, isolated from Rhizomucor pusillus, has been determined to be Cys2--Cys7, Cys12--Cys24, Cys13--Cys30, and Cys14--Cys21 by disulfide mass mapping based on partial reduction and CN-induced cleavage enabled by cyanylation. The

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