C2659

Chromomycin A₃

from Streptomyces griseus, ≥95% (HPLC), powder, RNA synthesis inhibitor

• 别名: Aburamycin B, CMA₃, NSC 58514
• 经验公式（希尔记法）: C₅₇H₈₂O₂₆
• CAS号: 7059-24-7
• 分子量: 1183.25
• EC 号: 230-348-0
• MDL编号: MFCD00043151
• UNSPSC代码: 41106305
• PubChem化学物质编号: 24892514
• NACRES: NA.77

属性

• 产品名称: 色霉素A₃ 来源于灰色链霉菌, ≥95% (HPLC)
• 质量水平: 200
• 方案: ≥95% (HPLC)
• 表单: powder
• 抗生素抗菌谱: Gram-positive bacteria; fungi; neoplastics
• 作用机制: DNA synthesis | interferes
• 储存温度: −20°C
• SMILES字符串: CO[C@H]1[C@@H](O)CC(O[C@H]1C)O[C@H]2CC(O[C@@H](C)[C@H]2OC(C)=O)Oc3cc4cc5C[C@@H]([C@@H](OC)C(=O)[C@@H](O)[C@H](C)O)[C@H](OC6C[C@@H](OC7C[C@H](OC8C[C@](C)(O)[C@@H](OC(C)=O)[C@H](C)O8)[C@@H](O)[C@H](C)O7)[C@H](O)[C@@H](C)O6)C(=O)c5c(O)c4c(O)c3C
• InChI: 1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3/t22-,23-,24+,25-,26-,27-,32-,33-,35+,36-,37-,38?,39?,40?,41?,42?,46-,47+,48-,52+,53+,54+,55-,56-,57-/m0/s1
• InChI key: ZYVSOIYQKUDENJ-MTPXVABGSA-N

说明

一般描述

Chemical structure: aureolic acid

应用

Chromomycin A3 from Streptomyces griseus has been used as a reagent in flow sorting.[1] It has also been used to stain spermatozoa to evaluate the sperm nuclear chromatin integrity.[2]

生化/生理作用

Chromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities.[3] It serves as a fluorescent DNA stain.[4] It is useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.

特点和优势

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全信息

• 象形图: GHS06
• 警示用语：: Danger
• 危险声明: H300
• 预防措施声明: P264 - P270 - P301 + P310 - P405 - P501
• 危险分类: Acute Tox. 1 Oral
• 储存分类代码: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges