推荐产品
形狀
solid
顏色
white
溶解度
H2O: >20 mg/mL
ethanol: 3.30 mg/mL
DMSO: >30 mg/mL
儲存溫度
2-8°C
SMILES 字串
Br[H].Br[H].Clc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1
InChI
1S/C14H17ClN4S.2BrH/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13;;/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);2*1H
InChI 密鑰
JIJQPEZAVLJZBO-UHFFFAOYSA-N
生化／生理作用
Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.
特點和優勢
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
吸湿
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
P Barrett et al.
Endocrinology, 150(8), 3655-3663 (2009-04-18)
Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage. Little is known, however, of the hypothalamic neuronal
J C Barnes et al.
European journal of pharmacology, 250(1), 147-152 (1993-11-30)
The pharmacological activity of the histamine H3 receptor antagonist VUF 9153 (S-[3-(4(5)-imidazolyl)]propyl-N-(4-chlorobenzyl)isothiourea) has been investigated in vitro and in vivo. VUF 9153 displaced [3H]N alpha-methylhistamine binding to rat cortex/hippocampal membranes (pKi = 9.77 +/- 0.03) and antagonised the inhibitory responses
Herman D Lim et al.
Bioorganic & medicinal chemistry, 17(11), 3987-3994 (2009-05-06)
Previous studies have demonstrated that clobenpropit (N-(4-chlorobenzyl)-S-[3-(4(5)-imidazolyl)propyl]isothiourea) binds to both the human histamine H(3) receptor (H(3)R) and H(4) receptor (H(4)R). In this paper, we describe the synthesis and pharmacological characterization of a series of clobenpropit analogs, which vary in the
Noelia A Massari et al.
Melanoma research, 21(5), 395-404 (2011-06-22)
We have previously reported that histamine at micromolar concentrations reduces the proliferation of melanoma cell lines. It is also known that melanoma cells express histamine H1, H2, and H3 receptors. The aim of this study was to investigate the presence
Brajesh K Rai et al.
Proteins, 78(2), 457-473 (2009-09-30)
G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that play important role in regulating key physiological functions, and are targets of about 50% of all recently launched drugs. High-resolution experimental structures are available only for very few GPCRs. As a
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