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Merck

C2020

Sigma-Aldrich

α-氰基-4-羟基肉桂酸

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

别名:

α-CCA, α-CHCA, α-氰基, 4-HCCA, ACCA

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10 G
$115.00
25 G
$239.00

About This Item

线性分子式:
HOC6H4CH=C(CN)CO2H
CAS号:
分子量:
189.17
Beilstein:
3271427
EC 号:
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77

$115.00


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产品名称

α-氰基-4-羟基肉桂酸, ≥98% (TLC), powder

方案

≥98% (TLC)

表单

powder

颜色

yellow

mp

245-250 °C (lit.)

溶解性

H2O: slightly soluble
methanol: water: soluble
polar organic solvents: soluble

储存温度

2-8°C

SMILES字符串

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

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应用

α5-氰基-4-羟基肉桂酸已被用于阻断单羧酸盐转运蛋白。[1][2]
α5-氰基-4-羟基肉桂酸是用于基质辅助激光解吸/电离飞行时间(MALDI-TOF)质谱的一种有用的疏水性基质溶液。[3]将其用作基质溶液,成功地分析了抗生素、肽核酸(一类新的DNA模拟物)和质量高达66,000 Da的蛋白。

生化/生理作用

α-氰基-4-羟基肉桂酸可充当一元羧酸转运的特异性抑制剂,包括乳酸和丙酮酸的转运。[4][5][6]据报道,其还可阻断β-细胞顶端阴离子交换(IC50 为2.4 mM)。[7]

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Skin Sens. 1B

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

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Lev-Vachnish Y, et al.
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J P Barnard et al.
The Journal of biological chemistry, 268(5), 3654-3661 (1993-02-15)
The protozoan parasite Trypanosoma brucei derives its metabolic energy exclusively from a unique type of glycolysis in which pyruvate derived from glucose catabolism is released into the host bloodstream. In this study, this terminal metabolic step has been examined in
C Emmons
The American journal of physiology, 276(4 Pt 2), F635-F643 (1999-04-13)
To functionally characterize transport properties of the apical anion exchanger of rabbit beta-intercalated cells, the mean change in anion exchange activity, dpHi/dt (where pHi is intracellular pH), was measured in response to lumen Cl- replacement with gluconate in perfused cortical
E T Sze et al.
Journal of the American Society for Mass Spectrometry, 9(2), 166-174 (1998-07-29)
We report a simple method for converting solid matrices into useful matrix solutions for matrix-assisted laser desorption/ionization (MALDI). This method is based on the dissolution of the solid matrix in a liquid support of low volatility such as glycerol. An
Elizabeth Csaszar et al.
Biotechnology and bioengineering, 103(2), 402-412 (2009-03-07)
An automated delivery system for cell culture applications would permit studying more complex culture strategies and simplify measures taken to expose cells to unstable molecules. We are interested in understanding how intracellular TAT-HOXB4 protein concentration affects hematopoietic stem cell (HSC)

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本页面介绍了一篇有关瓦博格效应的文章,以及其如何能够在正常氧气水平下,增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明,癌细胞显示出对糖酵解的依赖性增加,以满足他们的能量需求,无论是否有充足的氧气存在。

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Questions

1–2 of 2 Questions  
  1. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?

    1 answer
    1. α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.

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