This product corresponds to purified 'native' human C1q. Its sequence is not determined in-house. Please refer to published sequences, e.g. in GenBank for UniProt accession nos. P02745, P02746, & P02747.
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一般描述
C1q与C1r、C1s以1:2:2的比例形成C1复合物，它是经典补体途径的第一组分。C1q由18条多肽链（六个A、六个B、六个C）组成（MW 460 kDa）。它们都含有一个由靠近N-末端的(Gly-Xaa-Yaa)重复序列组成的81-aa胶原样区域。三条链（A1B1C1）形成一个三螺旋，C端形成球状头部，其在结构和功能上可能是不同的结构域。
应用
补体成分C1q是血小板活化的重要调节因子。这一直是一个研究课题，因为血小板白细胞聚集在炎性疾病（如冠心病）中发挥着重要作用。特别是，C1q可抑制胶原蛋白诱导的聚集，提高活性氧（ROS）的产生。
生化/生理作用
无论是由于罕见的纯合子遗传缺陷还是转录/翻译缺陷，C1q缺乏几乎可以肯定是系统性红斑狼疮（SLE）的病因。这三个C1q亚基是通过一种新的转录同步机制表达的。
外形
是10 mM HEPES、300 mM NaCl、pH 7.2的溶液
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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I ordered the C1740-1MG with lot#0000356664. I would like to know the protein sequences and the extinction coefficient about this protein?
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what is the size of the protein in WB ? when I test it's size it was approximately 24 KD ( the same size as c1q-c )
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C1q is composed of 18 polypeptide chains (six A, six B, six C). When prepared in denaturing sample buffer, and run on SDS PAGE, the chains will likely dissociate and run at their individual molecular weights. The Uniprot entries for C1qA, C1qB, and C1qC list masses of 26,017, 26,722, and 25,774, respectively.
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Is this product suitable for use in cell cultures?
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This product has not been tested for suitability in cell culture. The end user will need to determine suitability. However, there are multiple publications citing the use of this product in cell culture applications. Please see the link below to review an example:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377823/Helpful?
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Hola, me gustaría saber como se reconstituye el producto para su uso en ensayos. Gracias.
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This product is not suitable for use in clinical trials. Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
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What is the concentration of C1740?
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The product is supplied at a concentration of approximately 1 mg/ml. The exact concentration is lot specific and reported on the Certificate of Analysis.
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