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Merck

BM0023

Sigma-Aldrich

BMS-770767

≥98% (HPLC)

别名:

4-[8-(2-Chlorophenoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-bicyclo[2.2.1]heptan-1-ol

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About This Item

经验公式(希尔记法):
C19H18ClN3O2
分子量:
355.82
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

room temp

SMILES字符串

ClC1=C(OC2=CC=CN3C2=NN=C3[C@]4(C5)CC[C@]5(O)CC4)C=CC=C1

InChI

1S/C19H18ClN3O2/c20-13-4-1-2-5-14(13)25-15-6-3-11-23-16(15)21-22-17(23)18-7-9-19(24,12-18)10-8-18/h1-6,11,24H,7-10,12H2/t18-,19+

InChI key

HNXGIFYHJKEXNA-KDURUIRLSA-N

生化/生理作用

BMS-770767 is an inhibitor of 11-betahydroxysteroid dehydrogenase type I (11β-HSD1), which is a regulator of glucocorticoid activity and thought to play a possible role in metabolic syndrome. 11β-HSD1 can convert cortisol to the inactive metabolite cortisone, or catalyze the reverse reaction, converting inactive cortisone into active cortisol in cells. BMS-770767 was in clinical trials for hypercholesterolemia and Type 2 diabetes.
BMS-770767 is an inhibitor of 11-betahydroxysteroid dehydrogenase type I.

特点和优势

BMS-770767 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

法律信息

Sold for research purposes only under agreement from BMS.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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