推荐产品
方案
≥98% (HPLC)
表单
powder
颜色
off-white
溶解性
DMSO: >20 mg/mL
H2O: insoluble
创始人
Abbott
SMILES字符串
Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4
InChI
1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H
InChI key
RDNLAULGBSQZMP-UHFFFAOYSA-N
基因信息
human ... CHRM1(1128)
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生化/生理作用
Antiparkinsonian; non-selective muscarinic receptor antagonist.
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Laila Asth et al.
Brain research bulletin, 87(6), 526-533 (2012-03-08)
The elevated T-maze (ETM) is an apparatus derived from the elevated plus-maze test, which is used to evaluate anxiety. Because anxiety is a biasing factor in models of memory, this study proposed the ETM as a task for the simultaneous
Anna C Ramos et al.
Behavioural brain research, 231(1), 213-216 (2012-04-04)
Cocaine addiction is a public health issue in many countries, stressing the need for more effective treatments. As all drugs of abuse, cocaine acts on the brain reward system, increasing dopamine (DA) levels. Other neurotransmitters such as acetylcholine (ACh) are
A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden.
Sakae Takahashi et al.
The Journal of neuropsychiatry and clinical neurosciences, 25(1), E28-E28 (2013-03-15)
W Sperling et al.
Medical hypotheses, 76(5), 720-722 (2011-03-04)
In a regions of interest analysis (ROI) of the most frequent psychiatric disorders (schizophrenia, depression, anxiety, addiction), we found the nucleus lentiformis to be the topographical brain region most frequently cited in connection with these disorders in a regions of
Hormoz Ayromlou et al.
Archives of Iranian medicine, 14(2), 152-154 (2011-03-03)
The syndrome of hemiparkinsonism-hemiatrophy is an uncommon form of secondary Parkinsonism that presents with unilateral body Parkinsonism plus variable atrophy on the same side. Diagnosis of this syndrome needs a complete past medical history taking, as well as assessment of
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
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