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B1758

Sigma-Aldrich

Biocytin hydrochloride

≥98% (TLC), suitable for drug transporter assays

别名:

Nε-Biotinyl-L-lysine

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25 MG
$94.40
50 MG
$137.00
100 MG
$237.00
250 MG
$473.00

$94.40

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25 MG
$94.40
50 MG
$137.00
100 MG
$237.00
250 MG
$473.00

About This Item

经验公式（希尔记法）:
C16H28N4O4S · xHCl
CAS号:
98930-70-2
分子量:
372.48 (free base basis)
MDL编号:
MFCD00136057
UNSPSC代码:
12352209
PubChem化学物质编号:
24891609
NACRES:
NA.26

$94.40

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产品名称

Biocytin hydrochloride, ≥98% (TLC)

方案

≥98% (TLC)

表单

powder

技术

drug transporter assay: suitable

颜色

white to off-white

储存温度

−20°C

SMILES字符串

Cl.NC(CCCCNC(=O)CCCCC1SCC2NC(=O)NC12)C(O)=O

InChI

1S/C16H28N4O4S.ClH/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14;/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24);1H

InChI key

FMGQMNFQNPUYBS-UHFFFAOYSA-N

相关类别

应用


  • Biotinylated dextran amine and biocytin hydrochloride are useful tracers for the study of retinal projections in the frog.: This paper highlights the application of biocytin hydrochloride in tracing retinal projections in amphibians. The study demonstrates the efficacy of biocytin hydrochloride in neuroanatomical mapping, facilitating research in visual system development and function (Scalia et al., 1997).


生化/生理作用

Biocytin is used as a substrate to study the specificity and kinetics of biotinidase(s), to measure biotinidase deficiency and as a model compound to study various uptake mechanisms of cells and tissues.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000338556
0000338557
0000338555
0000274524
SLCQ8486

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Barry Wolf et al.
Molecular genetics and metabolism, 86(1-2), 44-50 (2005-09-10)
Biotinidases from various species ranging from fungi and insects to human have specific amino acids, and regions that are evolutionarily conserved. These specific amino acids and regions are further supported by their homology to a variety of amidases and nitrilases
Alessandro R Galloni et al.
eLife, 9 (2020-05-29)
Anatomical similarity across the neocortex has led to the common assumption that the circuitry is modular and performs stereotyped computations. Layer 5 pyramidal neurons (L5PNs) in particular are thought to be central to cortical computation because of their extensive arborisation
Margaret A MacNeil et al.
The Journal of comparative neurology, 506(1), 6-15 (2007-11-09)
The biocytin wide-field bipolar cell in rabbit retina has a broad axonal arbor in layer 5 of the inner plexiform layer and a wide dendritic arbor that does not contact all cones in its dendritic field. The purpose of our
Aysun Pabuçcuoğlu et al.
Journal of pediatric gastroenterology and nutrition, 34(1), 59-62 (2001-12-26)
Biotinidase is the enzyme responsible for liberating the vitamin biotin from biocytin and dietary protein-bound vitamin. Individuals lacking biotinidase activity become biotin deficient. Because the liver is the major source of plasma biotinidase, chronic liver diseases can lead to decreased
Barbara Baur et al.
Brain research, 925(2), 111-121 (2002-01-17)
Uptake of biocytin and biotin was investigated in cultured transformed variants of neuronal (NB2a neuroblastoma) and glial (C6 astrocytoma) CNS cells. NB2a cells took up both compounds but biocytin was transported more efficiently than biotin in the nanomolar concentration range.
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