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Merck

A5486

Sigma-Aldrich

偶氮甲烷

13.4 M, ≥98%

别名:

AOM

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25 MG
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25 MG
$810.00
100 MG
$2,590.00

About This Item

线性分子式:
CH3N=N(→O)CH3
CAS号:
分子量:
74.08
MDL號碼:
分類程式碼代碼:
12352124
PubChem物質ID:
NACRES:
NA.25

$810.00


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品質等級

化驗

≥98%

形狀

liquid

成份

methylene chloride, ≤1% (solvent)

儲存條件

(Keep container tightly closed in a dry and well-ventilated place.)

濃度

13.4 M

顏色

colorless

bp

97-99 °C (lit.)

密度

0.991 g/mL at 25 °C (lit.)

應用

genomic analysis

儲存溫度

−20°C

SMILES 字串

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI 密鑰

DGAKHGXRMXWHBX-ONEGZZNKSA-N

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一般說明

偶氮甲烷(AOM)是一种功能强大的实验室化学品,用于研究癌症,特别是结肠癌的发生、进展和预防。它可用作引发肿瘤形成的致癌物和导致DNA特异性改变的基因突变剂。

應用

氧化偶氮甲烷(AOM),一种基因突变剂,可与硫酸葡聚糖钠(DSS)一起用于在实验室动物中创建癌症模型,从而用于研究癌症进展和化学预防的机制。

生化/生理作用

诱导DNA中O6-甲基鸟嘌呤加合物的致癌物导致G→A转变。 在实验动物的结肠中诱导肿瘤生成,并用于研究癌症进展和化学预防的机制。

特點和優勢

用途广泛,适用于各种实验室和研究应用。

其他說明

为避免实验动物过早死亡,在实验设计中确定合适的氧化偶氮甲烷剂量至关重要。
如需了解生化试剂系列的更多信息,请填写此表

相關產品

产品编号
说明
价格

訊號詞

Danger

危險分類

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

75.2 °F

閃點(°C)

24 °C


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that results from massive loss of hepatocytes and may lead to hepatic encephalopathy (HE), a serious neuropsychiatric complication. Although increased expression of tumor necrosis factor-alpha

Questions

1–10 of 11 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the solubility of product A5486 (Azoxymethane, CAS number 25843-45-2)?

    1 answer
    1. The solubility of Azoxymethane (CAS 25843-45-2) is as follows:

      • Water solubility: approximately 100mg/mL
      • DMSO solubility: approximately 100mg/mL
      • Ethanol (95%) solubility: approximately 100mg/mL
      • Acetone solubility: approximately 100mg/mL

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  4. Could I know the concentration (mg/ml) and volume of Azoxymethane 13.4M in A5486-100MG?

    1 answer
    1. This product is considered to be a pure/neat chemical (not in solution), with a purity specification of at least 98%. The g/mL would be the density, of 0.991 g/mL. The volume of 100 mg is going to be approximately 100.9 microliters, but products are often over-filled by a few percent, so it would be recommended to still weigh the material during or prior to use.

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  5. Is Axozymethane volatile?

    1 answer
    1. Yes, this compound is considered to be a volatile substance. Please review the entire Safety Data Sheet before handling it.

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  6. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    1 answer
    1. No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

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  8. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  9. What are the approximate volumes for the of 25 mg and 100 mg, package sizes of Product No. A5486, Azoxymethane?

    1 answer
    1. Using the literature value for density of approximately 0.991 g/mL (at 25 °C), the approximate volumes are 25 μL for the 25 mg package size and 100 μl for the 100 mg package size.

      Helpful?

  10. How does azoxymethane act to cause cancers?

    1 answer
    1. Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

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