A2478

APHA Compound 8

solid, ≥98% (HPLC)

• 别名: 3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
• 经验公式（希尔记法）: C₁₆H₁₆N₂O₃
• CAS号: 676599-90-9
• 分子量: 284.31
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329770785
• NACRES: NA.77

属性

• product name: APHA Compound 8, ≥98% (HPLC), solid
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 溶解度: DMSO: >10 mg/mL; H₂O: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2
• InChI: 1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+
• InChI 密鑰: UFQOXIMRSMFQRI-BQYQJAHWSA-N

说明

生化／生理作用

One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.

安全信息

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H317,H318
• 防範說明: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• 危險分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves