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Merck

A0637

Sigma-Aldrich

DL-2-氨基己二酸

≥99% (TLC), powder, gliotoxic

别名:

DL-α氨基己二酸

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1 G
$216.00
5 G
$531.00
10 G
$914.00

About This Item

线性分子式:
HO2C(CH2)3CH(NH2)CO2H
CAS号:
分子量:
161.16
EC 号:
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.32

$216.00


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产品名称

DL-2-氨基己二酸, ≥99%

方案

≥99%

表单

powder

mp

196-198 °C (lit.)

储存温度

2-8°C

SMILES字符串

NC(CCCC(O)=O)C(O)=O

InChI

1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)

InChI key

OYIFNHCXNCRBQI-UHFFFAOYSA-N

基因信息

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应用

DL-2-氨基己二酸(AAA)已被用作一种astrotoxin 毒素,用于杀死可阻止移植的细胞有效整合到视网膜中的星形胶质细胞。它还被用作胶质毒素来研究星形胶质细胞膨胀对弯曲度的影响。[1]

生化/生理作用

DL-2-氨基己二酸(AAA)是谷氨酸盐的六碳同系物[2]和胶质毒性化合物。[3]它通常用于显著减少小脑培养物中的星形胶质细胞数目,该培养物可用作研究a-氨基己二酸诱导的神经胶质毒性机制的模型。[2]

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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H Q Wu et al.
European journal of pharmacology, 281(1), 55-61 (1995-07-25)
L-alpha-Aminoadipic acid is a lysine metabolite with neuroexcitatory properties, and has previously been shown to inhibit the production of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid in brain tissue slices. The effects of L-alpha-aminoadipic acid on the
Gliotoxin-induced swelling of astrocytes hinders diffusion in brain extracellular space via formation of dead-space microdomains
Sherpa AD, et al.
Glia, 62(7), 1053-1065 (2014)
Gliotoxic effects of $\alpha$-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellum
Huck S, et al.
Neuroscience, 12(3), 783-791 (1984)
Huadong Ni et al.
Journal of neuroinflammation, 16(1), 1-1 (2019-01-05)
Despite accumulating evidence on the role of glial cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role of chemokines in the descending facilitation of chronic pain. We aimed to study the hypothesis that
The toxic effect of sodium glutamate and DL-$\alpha$-aminoadipic acid on rat retina: Changes in high affinity uptake of putative transmitters
Karlsen RL, et al.
Journal of Neurochemistry, 31(4), 1055-1061 (1978)

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