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D8906

Sigma-Aldrich

硫酸葡聚糖 钠盐 来源于明串珠菌 属

for molecular biology, average Mw >500,000 (dextran starting material), contains 0.5-2% phosphate buffer

别名:

6-O-(6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基)-D-葡萄糖, 甘露三糖

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5 G
$122.00
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$185.00
50 G
$527.00
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$811.00
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$3,650.00

$122.00

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选择尺寸

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5 G
$122.00
10 G
$185.00
50 G
$527.00
100 G
$811.00
500 G
$3,650.00

About This Item

CAS号:
9011-18-1
MDL编号:
MFCD00081551
UNSPSC代码:
12352201
NACRES:
NA.31

$122.00

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生物来源

synthetic

质量水平

300

等级

Molecular Biology
for molecular biology

表单

powder

分子量

average Mw >500,000 (dextran starting material)

包含

0.5-2% phosphate buffer

组成

Sulfur Content, 16.0-19.0%

技术

FISH: suitable
FTIR: suitable

颜色

off-white

有效pH范围

6.0-8 (10 g/L)

溶解性

H2O: 100 mg/mL

适用性

suitable for marker for electrophoresis
suitable for nucleic acid hybridization

应用

genomic analysis
sample preparation

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相关类别

一般描述

硫酸葡聚糖(Dextran sulfate, DSS)是人工合成的葡聚糖（葡萄糖分子组成的复杂多糖）硫酸酯化衍生物。DSS是高度分支的生物相容性多糖，具有1–6和1–4糖苷键，每个葡糖残基约含2.3个硫酸基团。硫酸葡聚糖是一种硫酸酯化多糖，分子量范围5-1,400 kDa。广泛用于分子生物学和生物化学研究，特别适合胃肠道研究。硫酸葡聚糖是备受认可的炎症性肠病(IBD)造模剂，可诱发小鼠的结肠炎。硫酸葡聚糖是备受认可的炎症性肠病(IBD)造模剂，可诱发小鼠的结肠炎。通过调节浓度和给药频率，可制造急性、慢性和复发IBD模型。另外，硫酸葡聚糖也用于多种分子生物学实验，包括沉淀脂蛋白、加快DNA探针杂交、促进核糖体分离。值得一提的是，硫酸葡聚糖还可作为好用的壳聚糖交联剂，用于制备药物控释系统的微颗粒和纳米颗粒。除此之外，硫酸葡聚糖还在许多研究领域发挥重要作用，特别是在免疫学和病毒学中，它可激活免疫应答、增强体液免疫、影响B淋巴细胞活化、影响胸腺细胞对凝集素的反应。

应用

硫酸葡聚糖用于

  • 作为分子量标记，用于凝胶电泳测定纯化多糖的纯度和均一性[1]
  • 作为荧光原位杂交(FISH)实验杂交缓冲液组分，用于DNA检测和分析[2][3]
葡聚糖硫酸酯具有许多用途，当进行核酸杂交时可用作缩短探针退火所需时间的促进剂。当杂交速率成为检测稀有序列的限制因子时或当可用探针数量有限时，可在杂交缓冲液中加入葡聚糖硫酸酯。葡聚糖硫酸酯通过从聚合物所占溶液体积中扣除核酸而发挥促进剂的作用，从而提高有效的探针浓度。

生化/生理作用

硫酸葡聚糖是一种硫酸酯化多糖，可稳定地诱导实验性急性和慢性结肠炎。它被认为主要通过直接作用于上皮细胞，引起黏膜损伤和炎症。进而激活巨噬细胞和T淋巴细胞，最终导致细胞因子介导的细胞毒性。

特点和优势

  • 适用于核酸杂交&分子生物学
  • 硫酸葡聚糖平均分子量>500,000
  • 硫含量16.0-19.0 %
  • 用途广泛，适用于各种实验室和研究应用

适用性

已测试了在核酸杂交中的适应性

其他说明

为了全面了解我们针对客户研究提供的各种葡聚糖产品，建议您访问我们的碳水化合物分类页面。
如需了解生化试剂系列的更多信息，请填写此表。

可比产品

产品编号
说明
价格

D8787

硫酸葡聚糖 钠盐 来源于明串珠菌 属, avg mol wt >500,000 (dextran starting material)

D6001

硫酸葡聚糖 钠盐 来源于明串珠菌 属, average mol wt >500,000 (dextran starting material), contains 0.5-2.0% phosphate buffer, pH 6-8

D4911

硫酸葡聚糖 钠盐 来源于明串珠菌 属, mol wt 6,500-10,000

D6924

硫酸葡聚糖 钠盐 来源于明串珠菌 属, average mol wt 9,000-20,000

31395

硫酸葡聚糖 钠盐 来源于明串珠菌 属, Mr ~500,000

31404

硫酸葡聚糖 钠盐 来源于明串珠菌 属, Mr 5,000

52423

硫酸葡聚糖 钠盐 来源于明串珠菌 属, low sulfate content, Mr ~40,000

38739

硫酸葡聚糖 钠盐 来源于明串珠菌 属, low sulfate content

40357

硫酸葡聚糖 钠盐 来源于明串珠菌 属, low sulfate content

68841

硫酸葡聚糖 钠盐 来源于明串珠菌 属, Mr ~20,000

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM9776
BCCM7086
BCCM7085
0000306696
0000306696

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A fucoidan fraction purified from Chnoospora minima; a potential inhibitor of LPS-induced inflammatory responses
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International Journal of Biological Macromolecules, 104, 1185-1193 (2017)
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Reproduction (Cambridge, England), 149(1), 43-54 (2014-10-23)
The protamine 1 (Prm1) and sperm mitochondria-associated, cysteine-rich protein (Smcp) mRNAs exemplify a widespread pattern of mRNA-specific regulation of mRNA translation in post-meiotic spermatogenic cells, spermatids. Both mRNAs are transcribed and initially stored in free-mRNPs in early spermatids, and translated
Bhavana Tiwari et al.
Current biology : CB, 27(19), 3010-3016 (2017-10-03)
Retrotransposons are a pervasive class of mobile elements present in the genomes of virtually all forms of life [1, 2]. In metazoans, these are preferentially active in the germline, which, in turn, mounts defenses that restrain their activity [3, 4].
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During development of adenovirus-based vaccines, samples have to be analyzed in order to either monitor the production process or control the quality and safety of the product. An important quality attribute is the total concentration of intact adenoviruses, which currently
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Wnt signaling regulates multiple aspects of vertebrate central nervous system (CNS) development, including neurogenesis. However, vertebrate genomes can contain up to 25 Wnt genes, the functions of which are poorly characterized partly due to redundancy in their expression. To identify
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商品

Fluorescent in situ Hybridization (FISH)

Available Fluorescent in situ hybridization (FISH) procedures, reagents and equipment.

荧光原位杂交（FISH）

可用的荧光原位杂交（FISH）过程、试剂和设备。

实验方案

硫酸葡聚糖

硫酸葡聚糖以钠盐形式供应，使其在水中可溶且稳定。硫酸葡聚糖含有大约17%的硫，相当于每个葡糖基残基大约有2.3个硫酸基团。

Dextran Sulfate

Dextran sulfates as sodium salts are water-soluble and stable, containing approximately 17% sulfur for various applications.

相关内容

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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