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D6924

Sigma-Aldrich

硫酸葡聚糖 钠盐 来源于明串珠菌 属

average mol wt 9,000-20,000

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About This Item

CAS号:
9011-18-1
MDL號碼:
MFCD00081551
分類程式碼代碼:
12352201
NACRES:
NA.21

生物源

bacterial (Leuconostoc mesenteroides)

品質等級

200

形狀

powder

光學活性

[α]/D 90 to 105 °, c = 6% (w/v)

分子量

average mol wt 9,000-20,000

成份

Sulfur Content, 16.0-19.0%

顏色

white to off-white

有用的pH值範圍

5.5 - 8.0

溶解度

H2O: 100 mg/mL

儲存溫度

room temp

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相关类别

一般說明

葡聚糖硫酸钠是α-1,6-D-吡喃葡萄糖的天然聚合物。它是一种亲水性、可生物降解和生物相容性的聚阴离子聚合物。这种高度分枝的多糖具有1,6和1,4糖苷键，每个糖基单位由2.3个硫酸盐基组成。

應用

来自明串珠菌属的右旋糖酐硫酸钠已用于：
  • 评价硫酸盐聚糖参与重组人前顶蛋白/顶蛋白与透明带（ZP）糖蛋白相互作用
  • 将胚胎第5天的小鸡胚胎注射入玻璃体腔，以评估眼睛大小，并研究其对视网膜细胞增殖的影响
  • 检测TNF-刺激基因6（TSG-6）与固定化透明质酸（HA）结合的结构特异性

生化／生理作用

硫酸右旋糖酐可能具有抗凝血和抗病毒的特性。它还有助于降低胆固醇水平。在医疗领域广泛用作血浆体积膨胀剂和纤溶剂。硫酸右旋糖酐也可用作壳聚糖的交联剂。

其他說明

为了全面了解我们针对客户研究提供的各种葡聚糖产品，建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
0000368311
0000302329
0000305502
0000304916
0000308299

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Willi Halfter
Investigative ophthalmology & visual science, 49(8), 3289-3298 (2008-03-26)
The vitreous body (VB) is a transparent, extracellular matrix structure that fills the vitreous cavity of the eye. Major constituents of the VB are hyaluronic acid (HA) and glycosaminoglycans (GAGs), both of which are highly charged, linear carbohydrate polymers. The
Osama A Madkhali et al.
Scientific reports, 11(1), 9914-9914 (2021-05-12)
The purpose of this study was to develop a novel nano antibacterial formulation of dextran sulfate sodium polymer. The dextran sulfate sodium (DSS) nanoparticles were formulated with gelation technique. The nanoparticles exhibited significant physicochemical and effective antibacterial properties, with zeta
Hans-Georg Wisniewski et al.
The Journal of biological chemistry, 280(15), 14476-14484 (2005-02-09)
TSG-6 protein, up-regulated in inflammatory lesions and in the ovary during ovulation, shows anti-inflammatory activity and plays an essential role in female fertility. Studies in murine models of acute inflammation and experimental arthritis demonstrated that TSG-6 has a strong anti-inflammatory
Laura I Furlong et al.
Fertility and sterility, 83(6), 1780-1790 (2005-06-14)
To characterize proacrosin/acrosin interaction with isolated zona pellucida (ZP) components. Prospective study. Basic research laboratory. Recombinant proteins derived from human proacrosin (Rec-40, Rec-30, Rec-20, Rec-10, and Rec-6) and from human ZP glycoproteins (rec-hZPA, ZPB, and ZPC). In vitro binding assay
Yi-Nan Zhang et al.
ACS nano, 14(8), 9478-9490 (2020-06-02)
Nanovaccines need to be transported to lymph node follicles to induce humoral immunity and generate neutralizing antibodies. Here, we discovered that subcapsular sinus macrophages play a barrier role to prevent nanovaccines from accessing lymph node follicles. This is illustrated by
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硫酸葡聚糖

硫酸葡聚糖以钠盐形式供应，使其在水中可溶且稳定。硫酸葡聚糖含有大约17%的硫，相当于每个葡糖基残基大约有2.3个硫酸基团。

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