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生物来源
human liver
质量水平
表单
buffered aqueous solution
比活
≥1,500 units/mg protein (E1%/280)
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... CTSB(1508)
一般描述
生化/生理作用
发现切割前体蛋白1和前体蛋白11，并诱导洋地黄皂苷通透的细胞凋亡。
已经发现组织蛋白酶B切割前痉挛1和前痉挛11，并诱导洋地黄皂苷通透的细胞凋亡。组织蛋白酶B从细胞质向细胞核的转移有助于胆盐诱导大鼠肝细胞凋亡。诱导细胞凋亡后12-24小时，PC12细胞组织蛋白酶B水平显著下降。
包装
包装规格取决于蛋白质含量
单位定义
在40℃条件下，当pH为6.0时，一个单位每分钟将从Z-Arg-Arg 7-氨基-4-甲基香豆素中释放1纳米摩尔的7-氨基-4-甲基香豆素。
外形
50 mM醋酸钠溶液，pH 5.0，含1 mM EDTA。
底物
抑制剂
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
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The refined 2.15 AX-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.
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Foods (Basel, Switzerland), 11(4) (2022-02-26)
This study aimed to evaluate the efficiency of microencapsulated apple polyphenols (MAP) in controlling cathepsin activity and texture, as well as inhibiting protein oxidation and metmyoglobin formation in lamb meat during frozen storage at -18 °C for 40 weeks. The
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Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.
组织蛋白酶B是具有广泛特异性的溶酶体半胱氨酸蛋白酶。本方案采用Nα–CBZ–Arg–Arg–7–酰胺基-4-甲基香豆素作为荧光检测组织蛋白酶B活性的底物。
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