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Merck
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文件

C5429

Sigma-Aldrich

Z-精氨酸-精氨酸-7-酰氨基-4-甲基香豆素 盐酸盐

别名:

Z-RR-AMC

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About This Item

经验公式（希尔记法）:
C30H39N9O6
CAS号:
136132-67-7
分子量:
621.69
MDL號碼:
MFCD00133576
分類程式碼代碼:
12352209
PubChem物質ID:
24892784
NACRES:
NA.32

形狀

powder

雜質

~4% isopropanol

儲存溫度

−20°C

SMILES 字串

Cl.CC1=CC(=O)Oc2cc(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12

InChI

1S/C30H39N9O6.ClH/c1-18-15-25(40)45-24-16-20(11-12-21(18)24)37-26(41)22(9-5-13-35-28(31)32)38-27(42)23(10-6-14-36-29(33)34)39-30(43)44-17-19-7-3-2-4-8-19;/h2-4,7-8,11-12,15-16,22-23H,5-6,9-10,13-14,17H2,1H3,(H,37,41)(H,38,42)(H,39,43)(H4,31,32,35)(H4,33,34,36);1H

InChI 密鑰

HLSNWWKWVKPXKI-UHFFFAOYSA-N

基因資訊

human ... CTSB(1508)
mouse ... CTSB(13030)
rat ... CTSB(64529)

Amino Acid Sequence

Z-Arg-Arg-AMC

應用

Z-精氨酸-精氨酸-7-氨基-4-甲基香豆素盐酸盐已用于：
  • 粪便提取物中蛋白酶酶谱分析中的组织蛋白酶B底物。
  • 组织蛋白酶B活性测定。
  • 作为荧光肽底物用于测定基质金属蛋白酶的活性。

基底

组织蛋白酶B的荧光底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Cathepsin D Substrate

Sigma-Aldrich

SCP0109

Cathepsin D Substrate

7-氨基-4-甲基香豆素 Chromophore for substrates

Sigma-Aldrich

A9891

7-氨基-4-甲基香豆素

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Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida). In addition, the mites are carriers of microorganisms and microbial adjuvant compounds that stimulate
Protective outcomes of low-dose doxycycline on renal function of Wistar rats subjected to acute ischemia/reperfusion injury
Cortes A L, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(1), 102-114 (2018)
Miguel G Ximénez-Embún et al.
PloS one, 11(1), e0145275-e0145275 (2016-01-07)
Climate change will bring more drought periods that will have an impact on the irrigation practices of some crops like tomato, from standard water regime to deficit irrigation. This will promote changes in plant metabolism and alter their interactions with
High pressure effects on the activities of cathepsins B and D of mackerel and horse mackerel muscle
Fidalgo L G
Czech Journal of Food Sciences, 7, 53-53 (2014)
Kai S Beckwith et al.
Nature communications, 11(1), 2270-2270 (2020-05-10)
Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human monocytes and macrophages. A type VII secretion system (ESX-1)
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商品

Enzymatic Assay of Cathepsin B

Cathepsin B is a lysosomal cysteine proteinase with broad specificity. This protocol uses Nα–CBZ–Arg–Arg–7–amido–4–methylcoumarin as the substrate for fluorometric detection of Cathepsin B activity.

组织蛋白酶B的酶活检测

组织蛋白酶B是具有广泛特异性的溶酶体半胱氨酸蛋白酶。本方案采用Nα–CBZ–Arg–Arg–7–酰胺基-4-甲基香豆素作为荧光检测组织蛋白酶B活性的底物。

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