226R-2

BCL2 (SP66) Rabbit Monoclonal Antibody

• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100; 500
• 偶联物: unconjugated
• 抗体形式: culture supernatant
• 抗体产品类型: primary antibodies
• 克隆: SP66, monoclonal
• 描述: For In Vitro Diagnostic Use in Select Regions (See Chart)
• 表单: buffered aqueous solution
• 种属反应性: human
• 包装: vial of 0.1 mL concentrate (226R-24); vial of 0.5 mL concentrate (226R-25); bottle of 1.0 mL predilute (226R-27); vial of 1.0 mL concentrate (226R-26); bottle of 7.0 mL predilute (226R-28)
• 制造商/商品名称: Cell Marque^®
• 技术: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• 同位素/亚型: IgG1
• 控制: tonsil
• 运输: wet ice
• 储存温度: 2-8°C
• 可视化: cytoplasmic
• 基因信息: human ... BCL2(596)

说明

一般描述

BCL2 is a protein associated with apoptosis regulation produced by the bcl-2 gene, located on chromosome 14q32.[1] BCL2 is comprised of an alpha (239 amino acids) and beta chain. BCL2 (and thus BCL2 alpha chain) is found in mitochondrial and nuclear membranes and in the cytosol rather than the cell surface. In normal lymphoid tissue, BCL2 (and BCL2 alpha) antibody reacts with small B-lymphocytes in the mantle zone and many cells within the T-cell areas. Anti-BCL2 alpha has shown consistent negative reaction on reactive germinal centers and positive staining of neoplastic follicles in follicular lymphoma.[2] This difference in staining pattern is not due to down regulation or decreased BCL2 mRNA, but largely to a post-translational mechanism with resultant decrease in protein levels. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymphoid lesions. Anti-BCL2 has been used as an indicator of minimal residual disease in the bone marrow of follicular lymphoma patients when staining is strong and uniform.[3]

联系

BCL2 Positive Control Slides, Product No. 226S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: [email protected]

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable