SMB00969

阿米替林代谢物，(±)-E-10-羟基化-

≥95% (HPLC)

• 别名: (±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[a,d]环庚烯-10-醇
• 经验公式（希尔记法）: C₂₀H₂₃NO
• CAS号: 64520-05-4
• 分子量: 293.40
• MDL號碼: MFCD00069200
• 分類程式碼代碼: 41116107
• NACRES: NA.77

属性

• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 技術: HPLC: suitable
• 顏色: white to yellow
• 儲存溫度: 2-8°C
• SMILES 字串: CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13
• InChI: 1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+
• InChI 密鑰: GHWBJXOKAFHZAI-SFQUDFHCSA-N

说明

一般說明

(E)-10-Hydroxy amitriptyline is a metabolite of Amitriptyline (brand name Elavil), a FDA-approved oral medicine for the treatment of major depressive and anxiety disorders, attention deficit hyperactivity disorder (ADHD), bipolar disorder, as well as migraines and neuropathic pain (fibromyalgia & postherpetic neuralgiapain). Amitriptyline acts mainly on the serotonin transporter (SERT) and moderately on the norepinephrine transporter (NET). Amitriptyline is metabolised by cytochrome P450 enzymes (demethylation by CYP2C19 & CYP3A4) in the liver to Nortriptyline, which also acts as a noradrenaline reuptake inhibitor and thereby potentiates the antidepressant effects of amitriptyline. Amitriptyline and Nortriptyline are subject to metabolisation by hydroxylation (by CYP2D6) and n-oxidation.

應用

Metabolomics research

生化／生理作用

阿米替林代谢物，三环抗抑郁剂；色谱标准品。

其他說明

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安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable