RDD039

咪唑

for molecular biology, ≥99% (titration), free-flowing, Redi-Dri^™

• 别名: 1,3-二氮杂-2,4-环戊二烯, 甘恶啉
• 经验公式（希尔记法）: C₃H₄N₂
• CAS号: 288-32-4
• 分子量: 68.08
• Beilstein: 103853
• MDL编号: MFCD00005183
• UNSPSC代码: 12352200
• NACRES: NA.21

属性

• 等级: Molecular Biology; for molecular biology
• 质量水平: 100
• 蒸汽压: <1 mmHg ( 20 °C)
• 产品线: Redi-Dri^™
• 方案: ≥99% (titration)
• 表单: crystalline powder
• 质量: free-flowing
• pH值（酸碱度）: 6.2-7.8 (25 °C)
• pKa (25 °C): 6.95
• 沸点: 256 °C (lit.)
• mp: 88-91 °C (lit.)
• 应用: diagnostic assay manufacturing
• 异质活性: DNase, RNase and protease, none detected
• SMILES字符串: c1c[nH]cn1
• InChI: 1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
• InChI key: RAXXELZNTBOGNW-UHFFFAOYSA-N

说明

一般描述

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.[1]

应用

特别适用于 pH 6.2-7.8 范围内的缓冲液

Imidazole has been used

• in the lysis, wash, and elution buffer for the purification of histidine tagged proteins[2]
• in gradient for the purification of histidine tagged proteins using nickel affinity chromatography[3]
• as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells[4]

生化/生理作用

Imidazole derivatives have antibacterial, antifungal and anticancer functionality.[1] It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy.[5] It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).[6]

特点和优势

• Qualified for molecular biology applications, DNase, Rnase, and protease free
• Redi-Dri^™ packaging controls moisture, eliminating clumps
• Crystalline powder remains free-flowing and much easier to use
• Safer to handle and weigh out for routine use in lab
• Less waste, loss of drying, while maintaining high quality

其他说明

For additional information on our range of Biochemicals, please complete this form.

法律信息

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

安全信息

• 象形图: GHS08,GHS05,GHS07
• 警示用语：: Danger
• 危险声明: H302,H314,H360D
• 预防措施声明: P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危险分类: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 闪点(°F): 293.0 °F - closed cup
• 闪点(°C): 145 °C - closed cup