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Merck

E6376

Sigma-Aldrich

红霉素

potency: ≥850 μg per mg

别名:

Erythromycin A

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25 G
$295.00
100 G
$935.00

About This Item

经验公式(希尔记法):
C37H67NO13
CAS号:
分子量:
733.93
Beilstein:
75279
EC 号:
MDL编号:
UNSPSC代码:
51282304
PubChem化学物质编号:
NACRES:
NA.76

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生物来源

Streptomyces erythreus

质量水平

表单

powder

效能

≥850 μg per mg

颜色

white

溶解性

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

SMILES字符串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

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一般描述

化学结构:大环内酯

应用

应用
红霉素是一种抗生素,是通过 红霉素链霉菌的某些菌株的生长而产生的。 该产品主要由红霉素A和少量红霉素B和C组成,推荐浓度为100 mg/L. 50至200mg/L的浓度范围也被证明可有效控制细菌的生长。 红霉素已被用作胃动素受体激动剂,以在体外阻断人气道中的呼吸糖结合物分泌, 并可用于质粒固化重组乳酸链球菌MG1363菌株的选择。

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用,特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱:该产品可以抗革兰氏阴性和革兰氏阳性细菌。

注意

该产品在37℃下在溶液中可保持稳定3天。 储备溶液应储存在2-8°C。

制备说明

该产品可以2mg/mL的浓度溶于水中,0.067%的水溶液的pH值为8.0-10.5。 它也可以50mg/mL的浓度溶于乙醇中,获得澄清、无色至淡黄色的溶液。 它易溶于醇、丙酮、氯仿、乙腈和乙酸乙酯中,但会与酸形成盐。 所有溶液应保证避光。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

蛋白质合成是一个复杂、多步骤过程,涉及到很多酶以及构象排列。但是,阻碍细菌蛋白质合成的大部分抗生素对该过程的干扰发生在70S细菌核糖体的30S亚基或50S亚基。

Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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