BP793

布地奈德

British Pharmacopoeia (BP) Reference Standard

• 别名: 16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
• 经验公式（希尔记法）: C₂₅H₃₄O₆
• CAS号: 51333-22-3
• 分子量: 430.53
• MDL编号: MFCD00083259
• UNSPSC代码: 41116107
• NACRES: NA.24

属性

• 等级: pharmaceutical primary standard
• API类: budesonide
• 表单: solid
• 保质期: limited shelf life, expiry date on the label
• 制造商/商品名称: BP
• 应用: pharmaceutical; pharmaceutical small molecule
• 包装形式: neat
• SMILES字符串: [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@H]5OC(CCC)O[C@@]45C(=O)CO
• InChI: 1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
• InChI key: VOVIALXJUBGFJZ-KWVAZRHASA-N
• 基因信息: human ... NR3C1(2908)

说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Budesonide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Budesonide Aqueous Nasal Spray

Budesonide Inhalation Powder, pre-metered

Budesonide Inhalation Powder

Budesonide Pressurised Inhalation

Budesonide Nebuliser Suspension

生化/生理作用

Budesonide is a second generation glucocorticoid with low systemic absorption. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis, and inflammatory bowel disease. It inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein in primary human bronchial epithelial cells. Budesonide is currently in clinical trials for the prevention of lung cancer. It shows inhibitory effects on benzo[a]pyrene-induced carcinogenesis of the lung in mice.

Second generation glucocorticoid with low systemic absorption; anti-inflammatory agent; inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein.

包装

Unit quantity: 110 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

其他说明

Sales restrictions may apply.

安全信息

• 象形图: GHS08,GHS07
• 警示用语：: Danger
• 危险声明: H302,H317,H361d,H372,H412
• 预防措施声明: P202 - P273 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• 危险分类: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - Skin Sens. 1 - STOT RE 1 Inhalation
• 靶器官: Adrenal gland
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable