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Merck

36687

Supelco

4-氨基吡啶

PESTANAL®, analytical standard

别名:

4-吡啶胺, 4AP, 对氨基吡啶, 氨吡啶

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About This Item

经验公式(希尔记法):
C5H6N2
CAS号:
分子量:
94.11
Beilstein:
105782
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

analytical standard

质量水平

产品线

PESTANAL®

保质期

limited shelf life, expiry date on the label

技术

HPLC: suitable
gas chromatography (GC): suitable

沸点

273 °C (lit.)

mp

155-158 °C (lit.)

应用

agriculture
environmental

包装形式

neat

SMILES字符串

Nc1ccncc1

InChI

1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)

InChI key

NUKYPUAOHBNCPY-UHFFFAOYSA-N

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一般描述

4-Aminopyridine is a small molecule potassium channel blocker[1], which stimulates the release of glutamate from nerve terminals and induces seizures.[2] It can also be used as a drug that aims to improve ambulatory impairment, a major symptom of multiple sclerosis disease.[1]

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

法律信息

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语:

Danger

危险分类

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

312.8 °F

闪点(°C)

156 °C

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats
Sadeghnia RH, et al.
Iranian Journal of Basic Medical Sciences, 20, 588-588 (2017)
4-Aminopyridine ameliorates experimental autoimmune neuritis in Lewis rats
Moriguchi K, et al.
Journal of Neuroimmunology, 305, 72-74 (2017)
R I Westphalen et al.
British journal of anaesthesia, 110(4), 592-599 (2012-12-06)
Presynaptic effects of general anaesthetics are not well characterized. We tested the hypothesis that isoflurane exhibits transmitter-specific effects on neurotransmitter release from neurochemically and functionally distinct isolated mammalian nerve terminals. Nerve terminals from adult male rat brain were prelabelled with
Massimo Avoli et al.
Neurobiology of disease, 52, 168-176 (2012-12-29)
4-Aminopyridine (4AP, 50 μM) induces interictal- and ictal-like discharges in brain slices including parahippocampal areas such as the entorhinal cortex (EC) but the relation between these two types of epileptiform activity remains undifined. Here, by employing field potential recordings in
Jens Claassen et al.
Journal of neurology, neurosurgery, and psychiatry, 84(12), 1392-1399 (2013-07-03)
The effects of 4-aminopyridine (4-AP) on downbeat nystagmus (DBN) were analysed in terms of slow-phase velocity (SPV), stance, locomotion, visual acuity (VA), patient satisfaction and side effects using standardised questionnaires. Twenty-seven patients with DBN received 5 mg 4-AP four times

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