22632

奎宁 盐酸盐 二水合物

tested according to Ph. Eur.

• 别名: 奎宁盐酸盐
• 经验公式（希尔记法）: C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• CAS号: 6119-47-7
• 分子量: 396.91
• Beilstein: 6112655
• EC 号: 205-001-1
• MDL编号: MFCD00151248
• UNSPSC代码: 12352210
• PubChem化学物质编号: 329752329
• NACRES: NA.25

属性

• Agency: USP/NF; tested according to Ph. Eur.
• 质量水平: 100
• 表单: solid
• 溶解性: water: soluble 0.25 mg in 5 ml
• 应用: pharmaceutical (small molecule)
• SMILES字符串: O.O.Cl.COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1
• InChI key: MPQKYZPYCSTMEI-FLZPLBAKSA-N

说明

应用

Quinine hydrochloride dehydrate has been used for fluorescent in situ detection of quinine in cinchona bark using UV resonance raman spectroscopy.[1] It has also been used as a actinometric system to measure the light-induced changes in ruthenium anticancer agent, NAMI-A.[2]

生化/生理作用

Quinine is a very effective anti-malarial treatment but is considered toxic for routine treatment due to the development of drug resistance in the malarial parasites. It acts as blood schizonticide.[3][4]Quinine reportedly blocks the membrane conductance of potassium in enteric neurons.[5]

安全信息

• 象形图: GHS08,GHS07
• 警示用语：: Danger
• 危险声明: H302,H317,H334
• 预防措施声明: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• 危险分类: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: dust mask type N95 (US), Eyeshields, Faceshields, Gloves