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生物源
rat
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
A5, monoclonal
物種活性
mouse, human
製造商／商標名
Chemicon®
技術
immunohistochemistry: suitable (paraffin)
同型
IgG2aκ
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... LAMC1(3915)
一般說明
层粘连蛋白是细胞外基质糖蛋白的一个家族，是基底膜的主要非胶原蛋白成分。它们与多种生物学过程有关，包括细胞粘附，分化，迁移，信号传导，神经突向生长和转移。胚胎发生、器官发生、创伤后愈合和癌症中都观察到此层粘连蛋白表达变化。发现层粘连蛋白具有促进神经突再生的能力，从而激发了层粘连蛋白。层粘连蛋白由3条不同的链组成：层粘连蛋白α，β和γ（以前分别为A，B1和B2）。以前认为是β链的γ1链包含类似于β链的结构域，但是，缺少分隔结构域I和II的短α区。通过同源重组使γ1链基因的两个等位基因失活的转基因小鼠的胚胎缺乏基底膜，表明层粘连蛋白γ1链对于层粘连蛋白异源三聚体组装是必需的。
免疫原
从小鼠EHS肿瘤制备基底膜蛋白。
應用
使用经验证可用于IH（P）的抗层粘连蛋白γ1抗体（克隆A5）检测层粘连蛋白γ1。
研究子类别
ECM蛋白
粘附（CAMs）
ECM蛋白
粘附（CAMs）
標靶描述
177kda
外觀
形式：纯化
纯化的大鼠免疫球蛋白溶于含有0.1 M Tris-甘氨酸（pH7.4）150mM NaCl和0.05%NaN3的缓冲液中。
分析報告
对照
结肠管状癌与纤维神经瘤
结肠管状癌与纤维神经瘤
其他說明
浓度：请参考批次特异性浓缩物的分析证书。
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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