The Human Cytokine Autoantibody IgG Panel PE-IgG Conjugate provided with the HCYTABG-17K kit measures all IgG isotypes, and its detection is IgG Fc-specific.
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About This Item
UNSPSC代码:
12161503
NACRES:
NA.84
To order a Milliplex® kit, please search for your analyte of interest.
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种属反应性
human
质量水平
制造商/商品名称
Milliplex®
技术
multiplexing: suitable
检测方法
fluorometric (Luminex® xMAP®)
储存温度
2-8°C
一般描述
Anti-cytokine antibodies occur frequently and are present in healthy individuals and patients with acquired immunodeficiency and autoimmune diseases. Cytokines offering protection against microbes can be targeted by cytokine autoantibodies, leading to life-threatening infections. Some infections associated with anti-cytokine antibodies include M. tuberculosis, Salmonella, S. aureus. E. coli, Histoplasma, and more. The presence of cytokine autoantibodies in autoimmune disease can influence disease severity and activity. These autoimmune diseases may include systemic lupus erythematosus, multiple sclerosis, Sjögren’s syndrome, rheumatoid arthritis, and acute respiratory distress syndrome. Measuring cytokine autoantibodies may be useful for disease monitoring and efficacy of treatment.The MILLIPLEX® Human Cytokine Autoantibody Expanded IgG Magnetic Bead Panel is a 23-plex kit to be used for the simultaneous detection of any or all of the listed analytes in serum and plasma samples.
应用
The MILLIPLEX® Human Cytokine Autoantibody Expanded IgG Panel is a bead-based qualitative assay based on the Luminex® xMAP® technology, which enables the simultaneous analysis of cytokine autoantibodies in human serum and plasma samples.
Analytes available:
Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti IL 8, Anti-IL-10, Anti-IL-12p40, Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, Anti-TNFα, Anti-IFNα2, Anti-GM-CSF, Anti-IL-2, Anti-IL-3, Anti-IL-4, Anti-Osteopontin, Anti-PF4, and Anti-IFNω
Panel Type: MAGNETIC Immune Response
Cross Reactivity: There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.
Research Category: Inflammation & ImmunologyResearch Sub-Category: Inflammation & Autoimmune Mechanisms;Inflammation
Analytes available:
Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti IL 8, Anti-IL-10, Anti-IL-12p40, Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, Anti-TNFα, Anti-IFNα2, Anti-GM-CSF, Anti-IL-2, Anti-IL-3, Anti-IL-4, Anti-Osteopontin, Anti-PF4, and Anti-IFNω
Panel Type: MAGNETIC Immune Response
Cross Reactivity: There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.
Research Category: Inflammation & ImmunologyResearch Sub-Category: Inflammation & Autoimmune Mechanisms;Inflammation
特点和优势
Design your multiplex kit by choosing available analytes within this panel.
法律信息
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
警示用语：
Warning
危险声明
危险分类
Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
储存分类代码
10 - Combustible liquids
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Could you please confirm whether the Human Cytokine Autoantibody IgG Panel PE-IgG Conjugate provided with the HCYTABG-17K kit recognizes all IgG subtypes? If so, could you indicate if it recognizes the FC region or H+L?
1 answer-
Helpful?
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Does the IgG-PE detection conjugate detect all isoforms of IgG?
1 answer-
The mean proportions of IgG subclasses in normal adult serum are as follows: IgG1: 60%, IgG2: 32%, IgG3: 4%, and IgG4: 4%. The conjugate has been tested directly with IgG1, IgG3, and IgG4 and was reactive with all three, indicating a high likelihood of reactivity with IgG2 as well. The antibody (polyclonal) was purified from human IgG Fc from human serum, making it likely to be reactive with all four isotypes.
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