8.51095

PyOxim

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• 别名: PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
• 经验公式（希尔记法）: C₁₇H₂₉F₆N₅O₃P₂
• CAS号: 153433-21-7
• 分子量: 527.38
• MDL编号: MFCD18643381
• UNSPSC代码: 12352126
• NACRES: NA.22

属性

• 产品名称: PyOxim, Novabiochem^®
• 质量水平: 300
• 产品线: Novabiochem^®
• 方案: ≥99.0% (HPLC)
• 表单: powder
• 反应适用性: reaction type: Coupling Reactions
• 制造商/商品名称: Novabiochem^®
• 应用: peptide synthesis
• 储存温度: 15-25°C
• SMILES字符串: F[P-](F)(F)(F)(F)F.[P](=[N+]3CCCC3)(N2CCCC2)(N1CCCC1)O\N=C(\C(=O)OCC)/C#N
• InChI: 1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
• InChI key: RDWDVLFMPFUBDV-PXMDEAMVSA-N

说明

一般描述

PyOxim ^[1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.

特点和优势

• Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
• Mediates coupling with low racemization or epimerization
• Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
• Excellent solubility in DMF and NMP

分析说明

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable