价格与库存信息目前不能提供
推荐产品
方案
≥97% (SDS-PAGE)
质量水平
表单
lyophilized
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
杂质
≤1 EU/μg Endotoxin (EU/μg TGF-β1)
运输
ambient
储存温度
−20°C
一般描述
CHO细胞中表达的重组人转化生长因子β1。可促进静息的人B淋巴细胞、神经胶质瘤细胞和三叉神经鞘瘤细胞的凋亡。在各种疾病中诱导细胞外基质积聚。
生化/生理作用
ED₅₀ = 0.04-0.1 ng/ml
警告
毒性：标准处理（A）
外形
由含50 µg BSA/µg TGF-β1、35％乙腈、0.1％TFA的无菌滤过溶液冻干。
重悬
溶解后，分装并冷冻保存（-20°C）。避免溶液反复冻融。储备溶液在-20°C下可稳定保存至多3个月。
用含有≥0.1％ HSA或BSA的4 mM无菌HCl复溶成浓度≥1 µg/m的溶液。
其他说明
Shibuya, H., et al. 1996.Science272, 1179.
Bottlinger, E.P., et al. 1995.Proc.Natl.Acad.Sci. USA93, 5877.
Lomo, J., et al. 1995.J. Immunol.154, 1634.
Marushige, K., and Marushige, Y. 1995.Anticancer Res.14, 2419.
Yamazaki, M., et al. 1994.Am. J. Pathol.144, 221.
Bottlinger, E.P., et al. 1995.Proc.Natl.Acad.Sci. USA93, 5877.
Lomo, J., et al. 1995.J. Immunol.154, 1634.
Marushige, K., and Marushige, Y. 1995.Anticancer Res.14, 2419.
Yamazaki, M., et al. 1994.Am. J. Pathol.144, 221.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Nagat Frara et al.
Connective tissue research, 59(1), 30-44 (2017-04-13)
Transforming growth factor beta 1 (TGFbeta-1) and connective tissue growth factor (CCN2) are important mediators of tissue repair and fibrosis, with CCN2 functioning as a downstream mediator of TGFβ-1. Substance P (SP) is also linked to collagen production in tenocytes.
Holly B Hindman et al.
Investigative ophthalmology & visual science, 51(4), 1935-1942 (2009-11-13)
Purpose. To characterize phenotypic differences between anterior and posterior corneal keratocytes after stimulation with the profibrotic agent transforming growth factor-beta1 (TGF-beta1) in vitro. Methods. Sixteen corneas from healthy felines were obtained immediately after death. Lamellar dissection was performed to separate
Hon Wai Koon et al.
The American journal of pathology, 177(5), 2300-2309 (2010-10-05)
Substance P (SP) and the neurokinin-1 receptor (NK-1R) are involved in the development of colitis and mucosal healing after colonic inflammation. We studied whether SP modulates colonic fibrosis by using a chronic model of trinitrobenzenesulfonic acid (TNBS)-induced colitis in wild-type
Jeeranan Manokawinchoke et al.
Cell death & disease, 10(10), 761-761 (2019-10-09)
Mechanical force regulates periodontal ligament cell (PDL) behavior. However, different force types lead to distinct PDL responses. Here, we report that pretreatment with an intermittent compressive force (ICF), but not a continuous compressive force (CCF), promoted human PDL (hPDL) osteogenic
M Herranz-Itúrbide et al.
Redox biology, 40, 101841-101841 (2021-01-26)
Liver is a unique organ in displaying a reparative and regenerative response after acute/chronic damage or partial hepatectomy, when all the cell types must proliferate to re-establish the liver mass. The NADPH oxidase NOX4 mediates Transforming Growth Factor-beta (TGF-β) actions
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