566330-M

SIRT1/2 Inhibitor VIII, Salermide

The SIRT1/2 Inhibitor VIII, Salermide, also referenced under CAS 1105698-15-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 别名: SIRT1/2 Inhibitor VIII, Salermide, N-(3-((2-Hydroxynaphthalen-1-ylmethylene)-amino)-phenyl)-2-phenyl-propionamide, SIRT1 Inhibitor VI, SIRT2 Inhibitor VIII
• 经验公式（希尔记法）: C₂₆H₂₂N₂O₂
• CAS号: 1105698-15-4
• 分子量: 394.47
• MDL编号: MFCD12912446
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: yellow
• 溶解性: DMSO: 5 mg/mL
• 储存温度: 2-8°C
• SMILES字符串: N(c2cc(ccc2)N=Cc3c4c(ccc3O)cccc4)C(=O)C(C)c1ccccc1
• InChI: 1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)
• InChI key: HQSSEGBEYORUBY-UHFFFAOYSA-N

说明

一般描述

A cell-permeable 2-hydroxy-naphthaldehyde that acts as an inhibitor against sirtuins SirT1 and SirT2, members of class III HDACs. Salermide effectively inhibits the activity of both SirT1 and SirT2 (by 80% at 100 and 25 µM, respectively), while its structural analogue Sirtinol (Cat. Nos. 566320 and 566321), at 100 µM concentration, inhibits SirT2 only by up to 60% and is of no effect against SirT1. Salermide is also shown to be at least 2-fold more potent than Sirtinol (both at 100 µM) in killing leukemia KG1A and lymphoma Raji cultures.

警告

Toxicity: Standard Handling (A)

其他说明

Lara, E., et al. 2009. Oncogene28, 781.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3