推荐产品
product name
α-淀粉样蛋白前体蛋白质调节剂, A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
orange
溶解度
methanol: 1 mg/mL
DMSO: 50 mg/mL
運輸包裝
wet ice
儲存溫度
−20°C
InChI
1S/C27H30F3N3O3/c1-17(2)25-26(36)32-22(16-34)15-19-14-21(12-13-23(19)33(25)3)31-24(35)7-5-4-6-18-8-10-20(11-9-18)27(28,29)30/h4-14,17,22,25,34H,15-16H2,1-3H3,(H,31,35)(H,32,36)/b6-4+,7-5+/t22-,25-/m0/s1
InChI 密鑰
WOLVEMPZUIFSII-IHHOKICGSA-N
一般說明
一种细胞渗透性PKC激活剂（PKCα的Ki=11.9 nM），有效增强淀粉样前体蛋白（APP）的非淀粉样α加工，但缺乏任何促肿瘤活性。
一种细胞渗透性苯并内酰胺衍生的PKC激活剂（PKCα的Ki=11.9 nM），即使在100 nM时，也可有效增强人成纤维细胞AG06848中淀粉样前体蛋白（APP）的非淀粉样α-加工。显示肿瘤促进活性显着丧失。
生化／生理作用
主要靶标
PKC
PKC
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标Ki：对于活化PKC为11.9 nMα
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。
其他說明
Kozikowski, A.P., et al. 2003.J. Med. Chem.46, 364.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Sara Jiménez et al.
Cell reports methods, 3(7), 100512-100512 (2023-08-03)
Time-specific modulation of gene expression during differentiation by transcription factors promotes cell diversity. However, estimating their dynamic regulatory activity at the single-cell level and in a high-throughput manner remains challenging. We present FateCompass, an integrative approach that utilizes single-cell transcriptomics
Luiza Ghila et al.
Methods in molecular biology (Clifton, N.J.), 2454, 327-349 (2021-04-01)
Pancreatic islet endocrine cells generated from patient-derived induced pluripotent stem cells represent a great strategy for both disease modeling and regenerative medicine. Nevertheless, these cells inherently miss the effects of the intricate network of systemic signals characterizing the living organisms.
Yan Fung Wong et al.
Nature cell biology (2023-01-24)
Cell proliferation is fundamental for almost all stages of development and differentiation that require an increase in cell number. Although cell cycle phase has been associated with differentiation, the actual process of proliferation has not been considered as having a
Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture.
Braam, et al.
Scientific Reports, 13, 8877-8877 (2023)
Nina Sofi Funa et al.
Stem cell reports, 19(7), 973-992 (2024-06-29)
Genetic differences between pluripotent stem cell lines cause variable activity of extracellular signaling pathways, limiting reproducibility of directed differentiation protocols. Here we used human embryonic stem cells (hESCs) to interrogate how exogenous factors modulate endogenous signaling events during specification of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门