540500

Purvalanol A

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

• 别名: Purvalanol A, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
• 经验公式（希尔记法）: C₁₉H₂₅ClN₆O
• CAS号: 212844-53-6
• 分子量: 388.89
• MDL编号: MFCD02179211
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥97% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze
• 颜色: off-white
• 溶解性: DMSO: 100 mg/mL
• 运输: ambient
• 储存温度: −20°C
• SMILES字符串: Clc1cc(ccc1)Nc2nc(nc3[n](cnc32)C(C)C)N[C@@H](CO)C(C)C
• InChI: 1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
• InChI key: PMXCMJLOPOFPBT-HNNXBMFYSA-N

说明

一般描述

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2-cyclin B; IC₅₀ = 70 nM for Cdk2-cyclin A; IC₅₀ = 35 nM for Cdk2-cyclin E; and IC₅₀ = 75 nM for Cdk5-p35).

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2/cyclin B; IC₅₀ = 70 nM for Cdk2/cyclin A; IC₅₀ = 35 nM for Cdk2/cyclin E; and IC₅₀ = 75 nM for Cdk5/p35).

生化/生理作用

Cell permeable: yes

Primary Target
Cdc2/cyclin B

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Gray, N.S., et al. 1998. Science 281, 533.

法律信息

Sold under license of U.S. Patents 6,617,331 and 6,803,371.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3