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Merck

I7125

Sigma-Aldrich

5-碘-2′-脱氧尿苷

≥99% (HPLC)

别名:

1-(2-脱氧-β-D-呋喃核糖基)-5-碘尿嘧啶, 2′-脱氧-5-碘尿苷, 5-HIAA, IDU, IdUrd, 碘苷

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About This Item

经验公式(希尔记法):
C9H11IN2O5
CAS号:
分子量:
354.10
Beilstein:
30397
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (organic)

化驗

≥99% (HPLC)

形狀

powder or crystals

mp

194 °C (lit.)

溶解度

1 N NH4OH: 50 mg/mL, clear to very slightly hazy, colorless to light yellow

儲存溫度

2-8°C

SMILES 字串

OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(I)C(=O)NC2=O

InChI

1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI 密鑰

XQFRJNBWHJMXHO-RRKCRQDMSA-N

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應用

5-碘-2′-脱氧尿苷已用于分子梳检测或DNA纤维检测。
5-碘-2′-脱氧尿苷(5-IUdR;IdUrd)是一种嘧啶类似物(卤代胸苷),具有抗牛痘病毒(正痘病毒)活性。 IdUrd在人类癌症研究中被用作放射增敏剂。

生化/生理作用

5-碘-2′-脱氧尿苷可防止体外DNA病毒复制,疱疹病毒和痘病毒中可见这一现象。它具有致畸、促肿瘤、致突变和免疫抑制性。5-碘-2′-脱氧尿苷可用于外用治疗,有效抵抗上皮感染。

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險分類

Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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