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Merck
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文件

407331

Sigma-Aldrich

ILK抑制剂，Cpd 22

The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

ILK抑制剂，Cpd 22

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About This Item

经验公式（希尔记法）:
C30H30F3N5O
分子量:
533.59
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥94% (HPLC)

形狀

powder

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

off-white

溶解度

DMSO: 100 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

一般說明

一种细胞可渗透的三取代吡唑化合物，可作为有效和特异性整联蛋白连接激酶（ILK）抑制剂（IC50=600 nM）。显示对前列腺和乳腺癌细胞系具有高体外抗增殖效价（IC50 = 1 - 2.5 µM），同时保留正常上皮细胞。 其对癌症细胞的效应已归因于自噬和诱导的凋亡。抑制ILK介导的Ser473位点Akt磷酸化，从而下调下游靶标，如GSK-3b和肌球蛋白轻链。还引起转录因子Y-Box结合蛋白1（YB-1）的转录抑制。在小鼠模型中表现出最小毒性。
一种细胞可渗透的三取代吡唑化合物，可作为有效和特异性整联蛋白连接激酶（ILK）抑制剂（IC50=600 nM）。显示对前列腺和乳腺癌细胞系具有高体外抗增殖效价（IC50 = 1 - 2.5 M），同时保留正常上皮细胞。 其对癌症细胞的效应已归因于自噬和诱导的凋亡。抑制ILK介导的Ser473位点Akt磷酸化，从而下调下游靶标，如GSK-3b和肌球蛋白轻链。还引起转录因子Y-Box结合蛋白1（YB-1）的转录抑制。在小鼠模型中表现出最小毒性。

包裝

用惰性气体包装

警告

毒性：标准处理（A）

重構

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

Lee, S., et al. 2011.J. Med. Chem.54, 6364

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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