推荐产品
product name
CK-666, ≥98% (HPLC), powder
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to tan
溶解度
DMSO: ≥25 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F
InChI
1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChI 密鑰
UXRKUKRXVWJFER-UHFFFAOYSA-N
應用
CK-666可用于研究Arp2/3介导的细胞结构变化。
生化／生理作用
CK-666可结合Arp2/3复合物，稳定复合物的非活性状态，并防止其移动到活性构象。
CK-666是肌动蛋白相关蛋白Arp2/3复合物介导的肌动蛋白组装的细胞渗透性抑制剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
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Chemistry & biology, 20(5), 701-712 (2013-04-30)
Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to Arp2/3 complex and inhibit nucleation, but their modes of action are unknown. Here, we use biochemical and structural
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Formin is one of the two major classes of actin binding proteins (ABPs) with nucleation and polymerization activity. However, despite advances in our understanding of its biochemical activity, whether and how formins generate specific architecture of the actin cytoskeleton and
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PLoS genetics, 13(11), e1007107-e1007107 (2017-11-28)
Symmetry breaking is involved in many developmental processes that form bodies and organs. One of them is the epithelial rotation of developing tubular and acinar organs. However, how epithelial cells move, how they break symmetry to define their common direction
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