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描述
Merck USA index - 14, 4990
质量水平
方案
≥95% (SDS-PAGE)
表单
liquid
比活
≥2.8 x 108 units/mg protein
≥5 x 106 units/mL
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
avoid repeated freeze/thaw cycles
技术
cell based assay: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−70°C
基因信息
human ... IFNA1(3340)
一般描述
Research area: Immunoand cks
Interferons are cytokines secreted by mammalian cells. They are broadly divided into type I– interferon alpha (IFN-α) and interferon beta (IFN-β), type II – interferon-gamma (IFN-γ), and type III – interferon lambda (IFN-λ) based on their structure, function, and receptor specificity. Recombinant αA interferon is a hydrophobic protein belonging to the IFN-α family of proteins.[1]
Interferons are cytokines secreted by mammalian cells. They are broadly divided into type I– interferon alpha (IFN-α) and interferon beta (IFN-β), type II – interferon-gamma (IFN-γ), and type III – interferon lambda (IFN-λ) based on their structure, function, and receptor specificity. Recombinant αA interferon is a hydrophobic protein belonging to the IFN-α family of proteins.[1]
应用
Interferon alpha has been used to evaluate its effect on VSV (vesicular stomatitis virus) infection in pancreatic ductal adenocarcinoma (PDA) cell lines and study the relationship between type I IFNsignaling, resistance to VSV infection, and the JAK/STAT (Janus kinase/signal transducers and activators of transcription) signaling pathways in PDA cell lines.[2] It has also been used to study the inhibitory effect of Morbillivirus V Proteins on Interferon Signaling Pathways.[3]
生化/生理作用
Recombinant, human αA-interferon expressed in E. coli have antiviral, antiproliferative, antineoplastic, and immunomodulating properties. Recombinant interferon αA (IFN-αA) is used as the first line of treatment for hepatitis C.[1] It also displays a great therapeutic potential with chronic viral hepatitis, polycythemia, leukemia, and various other malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer.
警告
毒性：标准处理（A）
单位定义
每毫升培养基的一单位干扰素将导致牛MDBK细胞对VSV诱导的细胞病变性效应的50%抑制。相对于人αA-IFN的NIH国际标准品确定单位。在含有至少0.1%BSA或HSA的水性缓冲液中稀释。
外形
在含0.1% BSA的PBS中。
制备说明
仅在含蛋白的缓冲液（例如0.1%BSA）中稀释。
重悬
初次解冻后，分装冻存（-70°C）。
其他说明
Fujishima, H., et al. 1998.Int. J. Cancer 76, 423.
Haria, M., and Benfield, P. 1995.Drugs 50, 873.
Familletti, P.C., et al. 1981.Methods Enzymol.78, 387.
Haria, M., and Benfield, P. 1995.Drugs 50, 873.
Familletti, P.C., et al. 1981.Methods Enzymol.78, 387.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Expression of Soluble Active Interferon ?A in Escherichia coli Periplasm by Fusion with Thermostable Lichenase Using the Domain Insertion Approach
Tyurin AA, et al.
Biochemistry, 83(3), 259-269 (2018)
Morbillivirus V Proteins Exhibit Multiple Mechanisms to Block Type 1 and Type 2 Interferon Signalling Pathways
Senthil K, et al.
PLoS ONE, 8(2), e57063-e57063 null
Resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus: role of type I interferon signaling
Moerdyk-Schauwecker M, et al.
Virology, 436(1), 221-234 (2013)
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