401484

IKK-2 Inhibitor IV

InSolution, ≥95%

• 别名: InSolution IKK-2 Inhibitor IV
• 经验公式（希尔记法）: C₁₂H₁₀FN₃O₂S
• 分子量: 279.29
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: liquid
• 效能: 18 nM IC₅₀
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic); protect from light
• 颜色: clear pale yellow
• 运输: wet ice
• 储存温度: 2-8°C

说明

一般描述

IKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC₅₀ = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC₅₀ in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC₅₀ = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).

生化/生理作用

Cell permeable: yes

Product competes with ATP.

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 2
• 闪点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 闪点(°C): 87 °C - closed cup - (Dimethylsulfoxide)