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About This Item
经验公式（希尔记法）:
C10H9NO2S
CAS号:
分子量:
207.25
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
product name
Bay 11-7082, ≥98% (HPLC), powder
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white
溶解度
DMSO: >20 mg/mL
H2O: insoluble
SMILES 字串
Cc1ccc(cc1)S(=O)(=O)\C=C\C#N
InChI
1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChI 密鑰
DOEWDSDBFRHVAP-KRXBUXKQSA-N
應用
Bay 11-7082已用作：
- 细胞核因子kappa B(NF-kB)抑制剂，验证NF-kB信号通路在白介素(IL)-8产生中的作用
- 核因子kappa B(NF-kB)抑制剂，研究NF-kB活化在猪鼻支原体诱导上皮-间充质转化(EMT)和细胞迁移中的作用
- NOD样受体热蛋白结构域相关蛋白3(NLRP3)选择性抑制剂，研究其对造血干细胞移植小鼠的肝脏炎症的作用
生化／生理作用
Bay 11-7082可作为NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎性小体信号通路的选择性抑制剂。除了抑制核因子-kappa B(NF-kB)之外，Bay 11-7082还可诱发无核红细胞、人类T细胞白血病病毒I型(HTLV-I)感染T细胞系和原代成人T细胞白血病细胞的凋亡。
Bay 11-7082 是细胞因子诱导的 IκB-α 磷酸化的抑制剂。
特點和優勢
该化合物是基因调控研究的特色产品。点击此处查看更多特色基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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