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描述
RTECS - GM8925000
Merck USA index - 14, 4787
质量水平
方案
≥98% (TLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white to off-white
溶解性
ethanol: 15 mg/mL
运输
ambient
储存温度
10-30°C
SMILES字符串
O[C@]1([C@@]2([C@H]([C@H]3[C@@H]([C@]4(CCC(=O)C=C4CC3)C)[C@H](C2)O)CC1)C)C(=O)CO
InChI
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key
JYGXADMDTFJGBT-VWUMJDOOSA-N
一般描述
类固醇由肾上腺皮质合成。对于蛋白质、核酸和脂质代谢的调节至关重要。在药理上，氢化可的松可用于抑制炎症反应。
肾上腺皮质的一种类固醇激素，具有抗炎特性。
生化/生理作用
主要靶标
具有抗炎特性的肾上腺皮质的类固醇激素
具有抗炎特性的肾上腺皮质的类固醇激素
产物不与ATP竞争。
可逆：否
细胞渗透性：否
警告
毒性：致癌/致畸（D）
制备说明
可能需要加热至37°C才能完全溶解。
重悬
在复溶后存放于冰箱（4°C）。储备液可在4°C最长稳定1个月。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Repr. 1A - STOT RE 2
靶器官
Adrenal gland,Bone marrow
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Frontiers in immunology, 14, 1193535-1193535 (2023-11-30)
Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4+ T cells, is mostly studied in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence that Nrp1 is also highly expressed on activated effector T cells and
Hong-Yu Wu et al.
iScience, 27(6), 109850-109850 (2024-05-23)
Milk fat is an important indicator for evaluating the quality of cow's milk. In this study, we used bovine mammary epithelial cells (BMECs) to investigate the role and molecular mechanism of KLF4 in the regulation of milk fat synthesis. The
Lei Liu et al.
Journal of dairy science, 104(12), 12871-12880 (2021-09-07)
Susceptibility to mastitis is highest during the peripartal (transition) period and is often concomitant with other comorbidities such as ketosis. Although infection with pathogenic microorganisms and immune-dysfunction around calving clearly play key roles in mastitis development, other metabolic factors also
Laura Sanchez-Burgos et al.
Scientific reports, 12(1), 1626-1626 (2022-02-02)
The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory "cytokine storm" (CS) plays a determinant role. Here, we used transcriptomic data
Heather A McCauley et al.
Bio-protocol, 7(17), e2524-e2524 (2017-09-05)
Most epithelial tumors have been shown to contain cancer stem cells that are potentially the driving force in tumor progression and metastasis (Kreso and Dick, 2014; Nassar and Blanpain, 2016). To study these cells in depth, cell isolation strategies relying
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