373403

Hh/Gli Antagonist, GANT61

InSolution, ≥95%

• 别名: InSolution Hh/Gli Antagonist, GANT61, 2,2ʹ-(2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl) bis(methylene) bis(N,N-dimethylaniline), NSC 136476, 2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline
• 经验公式（希尔记法）: C₂₇H₃₅N₅
• CAS号: 500579-04-4
• 分子量: 429.60
• MDL编号: MFCD14635408
• UNSPSC代码: 51111800
• NACRES: NA.77

属性

• 质量水平: 100
• 方案: ≥95% (HPLC)
• 表单: liquid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 运输: dry ice
• 储存温度: −20°C
• SMILES字符串: CN(C)C1=CC=CC=C1CN2CCCN(CC3=CC=CC=C3N(C)C)C2C4=CC=NC=C4
• InChI: 1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
• InChI key: KVQOGDQTWWCZFX-UHFFFAOYSA-N

说明

一般描述

A cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC₅₀ ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells.

生化/生理作用

Cell permeable: yes

Primary Target
Gli1 and Gli2

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 25 mM (2 mg/186 µL) solution of Hh/Gli Antagonist, GANT61 (Cat. No. 373401) in DMSO.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 10 - Combustible liquids
• WGK: WGK 2
• 闪点(°F): 188.6 °F - closed cup - (refers to pure substance)
• 闪点(°C): 87 °C - closed cup - (refers to pure substance)