118490

ATIC Dimerization Inhibitor

• 别名: ATIC Dimerization Inhibitor, AMPK Signaling Activator XI, Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI
• 经验公式（希尔记法）: C₂₁H₃₃N₇O₅
• CAS号: 1402453-15-9
• 分子量: 463.53
• MDL编号: MFCD00214071
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥97% (HPLC)
• 质量水平: 100
• 表单: solid
• 效能: 691 nM K_i
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: white
• 溶解性: DMSO: soluble
• 运输: wet ice
• 储存温度: 2-8°C

说明

一般描述

A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (K_i = 691 nM, K_d = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040).

生化/生理作用

Cell permeable: yes

Primary Target
ATIC

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

Ac-Arg-Ph(4-NO2)-NEt2

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Spurr, I.B., et al. 2012. ChemBioChem13, 1628.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable