07-722
Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody
Upstate®, from rabbit
别名:
Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, kinase insert domain receptor (a type III receptor tyrosine kinase), vascular endothelial growth factor receptor 2
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所有图片(2)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
价格与库存信息目前不能提供
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生物来源
rabbit
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
zebrafish, human
种属反应性（根据同源性预测）
primate (based on 100% sequence homology), horse (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology), chicken (based on 100% sequence homology), bovine (based on 100% sequence homology), Danio (based on 100% sequence homology)
制造商/商品名称
Upstate®
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
phosphorylation (pTyr1054)
基因信息
human ... KDR(3791)
一般描述
The Flt gene family of receptor tyrosine kinases includes Flt-1, KDR/Flk-1, Flt-3, and Flt-4. They encode receptors for VEGF, characterized by seven Ig-loops within their extracellular domain and a split kinase domain within the cytoplasmic domain. VEGF is an important angiogenic factor of many solid tumors and is also involved in the differentiation of endothelial cells. Flt-1 (Fms-like tyrosine kinase, VEGF-R1) is expressed on endothelial cells and on the common precursors of endothelial and hematopoietic stem cells. KDR (Flk-1, VEGF-R2) is the principal receptor involved in VEGF signaling. KDR is expressed on endothelial cells and stimulates angiogenesis, but is also expressed on bone marrow cells, and is thought to play a role in driving the proliferation of most or all leukemic cells. Flt3 (also known as Flk-2) is a class III receptor tyrosine kinase that is closely related to c-Kit and c-Fms. It is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in co-operation with other cytokines.
特异性
Recognizes VEGFR2/Flk-1/KDR when phosphorylated on Tyrosine 1054 (human).
免疫原
Synthetic peptide encompassing
应用
Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody is an antibody against phospho-VEGFR2/Flk-1/KDR (Tyr1054) for use in WB.
Research Category
Signaling
Signaling
质量
Western Blot Analysis:
This lot detected VEGFR2 phosphorylated on Tyr1054 at a 1:1,000 dilution in PAE cells transfected with CSF/KDR and treated with 40ng/mL CSF-1 for 15 min. Cell lysate resolved via SDS-PAGE and transferred to PVDF (Immobilon-P).
This lot detected VEGFR2 phosphorylated on Tyr1054 at a 1:1,000 dilution in PAE cells transfected with CSF/KDR and treated with 40ng/mL CSF-1 for 15 min. Cell lysate resolved via SDS-PAGE and transferred to PVDF (Immobilon-P).
目标描述
152 kDa
外形
Double affinity purified
Affinity purified rabbit polyclonal IgG in PBS with 0.05% NaN3 and 50% glycerol.
储存及稳定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
分析说明
Control
CSF-1 treated PAE cell lysate, transfected with CSF/KDR.
CSF-1 treated PAE cell lysate, transfected with CSF/KDR.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
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