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C-053

Supelco

卡马西平标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C15H12N2O
CAS号:
298-46-4
分子量:
236.27
MDL號碼:
MFCD00005073
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

certified reference material

品質等級

300

形狀

liquid

特點

SNAP-N-SPIKE®, SNAP-N-SHOOT®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

濃度

1.0 mg/mL in methanol

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing

形式

single component solution

儲存溫度

−20°C

SMILES 字串

O=C(N)N1C2=C(C=CC=C2)C=CC3=C1C=CC=C3

InChI

1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

InChI 密鑰

FFGPTBGBLSHEPO-UHFFFAOYSA-N

基因資訊

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

相关类别

一般說明

卡马西平是一种抗惊厥和稳定情绪的药物，主要用于治疗癫痫和神经性疼痛。 卡马西平以Carbatrol®，Tegretol®，Carbamaze和Biston商品名销售，也用作双相障碍的二线治疗，并与抗精神病药联合用于精神分裂症。这种经认证的加标溶液®的适当用途包括在临床毒理学、疼痛处方监测、法医分析或治疗药物监测应用的GC/MS或LC/MS卡马西平检测方法中，作为制备校准品和质控品的起始物料。

應用


  • 卡马西平研究用溶液：研究侧重于开发钴氮共掺杂碳纳米管，用于卡马西平的活化过一硫酸盐降解，研究突出了其在环境清理和污染控制中的应用（Molecules, 2024; doi: 10.3390/molecules29071525）。

  • 抗惊厥生化试剂：卡马西平可用于活性炭的生产和表征研究，用于去除各种水源中的药物污染物，研究证了明其与可持续水处理技术相关。（Materials, Basel）。

  • 神经科学研究用化学品：去除水基质中药物的新型复合材料的研究以卡马西平为目标污染物，彰显了其在环境健康和安全研究中的重要性（ Environ Res, et.al）。

  • 离子通道抑制剂：去除药品残留物的新材料研究包括了卡马西平，该研究展示了其在创新水处理解决方案性能评估中的实用性（Carbohydr Polym, 2024）。

  • 癫痫药理学研究：研究涉及用于去除微污染物的LED驱动光-芬顿工艺，该研究强调了卡马西平在先进氧化工艺环境净化效果评估方面的应用（J Environ Manage, 2024）。

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Carbatrol is a registered trademark of Pharmavene, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Tegretol is a registered trademark of Novartis Corporation

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - Skin Sens. 1 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

分析证书(COA)

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Inge Anita Meijer et al.
Muscle & nerve, 49(1), 134-138 (2013-07-31)
Erythromelalgia due to heterozygous gain-of-function SCN9A mutations usually presents as a pure sensory-autonomic disorder characterized by recurrent episodes of burning pain and redness of the extremities. We describe a patient with an unusual phenotypic presentation of gross motor delay, childhood-onset
Emilie Caietta et al.
Pediatrics, 132(3), e784-e787 (2013-08-21)
Mutations of SCN4A encoding the skeletal muscle sodium channel Nav 1.4 cause several types of disease, including sodium channel myotonias. The latter may be responsible for neonatal symptoms, including severe neonatal episodic laryngospasm (SNEL). Establishing the diagnosis of SCN4A-related SNEL
U Amstutz et al.
Clinical pharmacology and therapeutics, 94(1), 142-149 (2013-04-17)
The occurrence of hypersensitivity reactions including rare but life-threatening Stevens-Johnson syndrome (SJS) and drug-induced hypersensitivity syndrome (HSS) limits the use of the anticonvulsant carbamazepine (CBZ). Human leukocyte antigen-B (HLA)-B 15:02 and HLA-A 31:01 have been identified as predictive genetic markers
V L Yip et al.
Clinical pharmacology and therapeutics, 92(6), 757-765 (2012-11-08)
Carbamazepine (CBZ) therapy is associated with cutaneous adverse reactions in up to 10% of patients. Predisposition to these hypersensitivity reactions has been linked to the human leukocyte antigen (HLA) genotype. This systematic review determines the strength of these associations and
Janneke Jentink et al.
BMJ (Clinical research ed.), 341, c6581-c6581 (2010-12-04)
To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy. A review of all published cohort studies to identify key indications and a population based case-control study to test these indications. Review of
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