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Merck

860634P

Avanti

C16 二氢神经酰胺(d18:0/16:0)

Avanti Research - A Croda Brand 860634P, powder

别名:

N-棕榈酰-D-赤型-二氢鞘氨醇

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About This Item

经验公式(希尔记法):
C34H69NO3
CAS号:
分子量:
539.92
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

powder

包裝

pkg of 1 × 10 mg (860634P-10mg)
pkg of 1 × 5 mg (860634P-5mg)

製造商/商標名

Avanti Research - A Croda Brand 860634P

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

InChI

1S/C34H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32-33,36-37H,3-31H2,1-2H3,(H,35,38)/t32-,33+/m0/s1

InChI 密鑰

GCGTXOVNNFGTPQ-JHOUSYSJSA-N

應用

C16二氢神经酰胺(d18:0/16:0)适用于研究在四氢大麻酚(THC)处理的细胞中自噬体和自溶酶体的鞘脂组成中观察到的变化的潜在相关性,或使生物膜不稳定。

生化/生理作用

二羟基神经酰胺是用于合成神经酰胺的前体。它具有诱导核周区域自噬的能力。二氢神经酰胺影响自噬通量并增强脂质滴的形成。C16-二氢神经酰胺的积累可能会导致肝损伤。

包裝

5 mL棕色玻璃螺旋盖小瓶(860634P-10mg)
5 mL棕色玻璃螺旋盖小瓶(860634P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


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Autophagy, 12(11), 2213-2229 (2016)
Md Abdullah Al Sazzad et al.
Langmuir : the ACS journal of surfaces and colloids, 32(23), 5973-5980 (2016-05-25)
To better understand the interactions of saturated ceramides with unsaturated glycerophospholipids in bilayer membranes, we measured how palmitoyl ceramide (PCer) and dihydroceramide (dihydro-PCer, lacking the trans 4 double bond of the sphingoid base of ceramide) can interact with phosphatidylcholines (PCs)
Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model
Lee Ah young, et al.
Biochemical and biophysical research communications, 494(3-4), 460-469 (2017)
Sonia Hernández-Tiedra et al.
Autophagy, 12(11), 2213-2229 (2016-11-02)
Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used Δ9-tetrahydrocannabinol (THC, the main

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