810189P

TopFluor^™ PI(3,4,5)P3

Avanti Research^™ - A Croda Brand 810189P, powder

• 别名: 1-oleoyl-2-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-sn-glycero-3-phosphoinositol-3,4,5-trisphosphate (ammonium salt)
• 经验公式（希尔记法）: C₅₆H₁₀₈ BF₂ N₇O₂₃P₄
• CAS号: 2260795-37-5
• 分子量: 1420.19
• MDL號碼: MFCD00036905
• 分類程式碼代碼: 12352211
• NACRES: NA.25

属性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 50 μg (with stopper and crimp cap (810189P-50ug))
• 製造商／商標名: Avanti Research^™ - A Croda Brand 810189P
• 運輸包裝: dry ice
• 儲存溫度: −20°C

说明

一般說明

PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor^™ PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain.[1]

Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid[2] present on the inner leaflet of the plasma membrane.[3]

生化／生理作用

PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor^™ PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores.[1]

Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals.[2] It also regulates the activity protein kinase B/Akt.[4]

包裝

2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

TopFluor is a trademark of Avanti Polar Lipids, LLC

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable