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Merck

I17451

Sigma-Aldrich

异烟酰胺

ReagentPlus®, 99%

别名:

吡啶-4-甲酰胺

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25 G
$54.30
100 G
$120.00

About This Item

经验公式(希尔记法):
C6H6N2O
CAS号:
分子量:
122.12
Beilstein:
2173
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

$54.30


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质量水平

产品线

ReagentPlus®

方案

99%

mp

155-157 °C (lit.)

SMILES字符串

NC(=O)c1ccncc1

InChI

1S/C6H6N2O/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9)

InChI key

VFQXVTODMYMSMJ-UHFFFAOYSA-N

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应用

异烟酰胺(吡啶-4-甲酰胺)可作为合成以下物质的杂环结构单元:
  • 潜在抗结核剂4-氧代-1,3-噻嗪烷-3-基异烟酰胺衍生物。[1]
  • 通过合成氨基磷酸酯配体制备的用于各种生物活性研究的异烟酰胺有机锡 (IV) 复合物。[2]
  • 2-(羟基亚氨基)-N-(吡啶-3-基)乙酰胺的双吡啶鎓异烟酰胺衍生物,其是一种强效活化剂沙林[2]

它还可用作共晶试剂(co-former),与活性药物成分(API)一起制备共晶体。[3]

法律信息

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

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New organotin (IV) complexes of nicotinamide, isonicotinamide and some of their novel phosphoric triamide derivatives: Syntheses, spectroscopic study and crystal structures
Gholivand K, et al.
Journal of Organometallic Chemistry, 695(9), 1383-1391 (2010)
QSAR, docking studies of 1, 3-thiazinan-3-yl isonicotinamide derivatives for antitubercular activity
Chitre TS, et al.
Computational Biology and Chemistry, 68, 211-218 (2017)
Jinjing Li et al.
Chemical communications (Cambridge, England), 47(5), 1530-1532 (2010-11-23)
For each of the well-known co-crystal formers, isonicotinamide and nicotinamide, a new polymorph, obtained during attempted co-crystallisation experiments, has been fully characterized and its stability relationship with previously reported forms established.
Yan Li et al.
European journal of pharmacology, 609(1-3), 13-18 (2009-03-17)
The phytoalexin resveratrol has been described to have chemopreventive and chemotherapeutic effects in several tumor models while its effects on osteosarcoma have not been extensively studied. Additionally, resveratrol is a potent activator of the Sirt1/Sir2 (silent information regulator 2) family
Srinu Tothadi et al.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 370(1969), 2900-2915 (2012-05-23)
The idea of a structural landscape is based on the fact that a large number of crystal structures can be associated with a particular organic molecule. Taken together, all these structures constitute the landscape. The landscape includes polymorphs, pseudopolymorphs and

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