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C7206

Sigma-Aldrich

Z-Gly-OH

99%

别名:

Z-甘氨酸

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25 G
$84.50
100 G
$243.00
500 G
$438.00

About This Item

线性分子式:
C6H5CH2OOCNHCH2COOH
CAS号:
1138-80-3
分子量:
209.20
Beilstein:
526877
EC 号:
214-516-0
MDL编号:
MFCD00002691
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
24892944
NACRES:
NA.22

$84.50

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方案

99%

表单

powder

反应适用性

reaction type: solution phase peptide synthesis

颜色

beige

mp

118-122 °C (lit.)

应用

peptide synthesis

SMILES字符串

OC(=O)CNC(=O)OCc1ccccc1

InChI

1S/C10H11NO4/c12-9(13)6-11-10(14)15-7-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13)

InChI key

CJUMAFVKTCBCJK-UHFFFAOYSA-N

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相关类别

一般描述

Z-Gly-OH又名N-苄氧羰基甘氨酸, 是一种氨基酸，广泛用于液相法多肽合成。

应用

Z-Gly-OH是多功能试剂，可合成各种化合物：
  • 甘氨酸衍生肽，如Z-Gly-DL-Ala-OBzl和Z-Gly-L-Ala-OBzl[1]
  • 甘氨酸N-取代酰胺，如甘氨酸-N-甲酰胺盐酸和甘氨酸-N-异丙酰胺盐酸[2]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SDBB2811
SDBB2120
SDBB0270
STBL0631
STBK8384

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Formation of peptide bonds in the coordination sphere of cobalt (III)
Journal of the American Chemical Society, 89, 6096-6103 (1967)
Studies on Separation of Amino Acids and Related Compounds. V. A Racemization Test in Peptide Synthesis by the Use of an Amino Acid Analyzer
Bulletin of the Chemical Society of Japan, 44, 3391-3395 (1971)
Duality of mechanism in the tetramethylfluoroformamidinium hexafluorophosphate-mediated synthesis of N-benzyloxycarbonylamino acid fluorides.
R Fiammengo et al.
The Journal of organic chemistry, 66(17), 5905-5910 (2001-08-21)
G K Scriba et al.
The Journal of pharmacy and pharmacology, 51(5), 549-553 (1999-07-20)
Glycine, which has weak anticonvulsant properties, has been shown to potentiate the activity of several antiepileptic drugs but not phenytoin. Recently, studies have shown that N-(benzyloxycarbonyl)glycine (Z-glycine) antagonized seizures more than glycine in addition to possessing activity in the maximal
D M Lambert et al.
Neuroreport, 5(7), 777-780 (1994-03-21)
Although glycine does not cross easily the blood-brain barrier, it exhibits at very high doses (10-40 mmol kg-1) a modest anticonvulsant activity. In this study, carbamate derivatives--N-benzyloxycarbonylglycine (Z-glycine) and N,tert-butoxycarbonylglycine (Boc-glycine)--have been compared with glycine. Z-glycine (1 mmol kg-1), but
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