$177.00
预计发货时间2025年5月09日详情
表单
powder or chunks (or Fibers)
质量水平
颜色
white to faint yellow-brown
储存温度
2-8°C
SMILES字符串
OC1[C@H](O[*])[C@@H](C(NN)=O)O[C@H]([C@@H]1O)O[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]([C@@H]3O)[C@@H](C(O[Na])=O)O[C@H]([C@@H]3O)O[C@H]4[C@H](O)[C@@H](CO)O[C@H]([C@@H]4NC(C)=O)[*])[C@@H]2NC(C)=O
一般描述
Hyaluronic acid hydrazide is a versatile and innovative functionalized natural polymer whereby the carboxylic acid moieties of hyaluronic acid are modified with mono- and polyfunctional hydrazides via controlled synthesis. Hyaluronic acid (HA), linear polysaccharide composed of alternating 1,4-linked units of 1,3-linnked glucuronic acid and N-acetylglucosamine, is a crucial component of the extracellular matrix (ECM). The hydrazide groups are highly reactive with aldehydes, leading to the formation of acyl hydrazone linkages. This is particularly useful for linking glycoproteins or carbohydrates in a site specific manner.
应用
- Hyaluronic acid hydrazide can be used for a wide range of applications. By harnessing the controlled hydrazide modification of hyaluronic acid, this product can be used to create tailored solutions for various fields, including biomedical research, pharmaceuticals, and tissue engineering.
- Applications include:
- Developing new drug delivery systems such as prodrugs
- Studying cell motility in 3D cell culture scaffolds
- Engineering biocompatible scaffolds and hydrogels for areas such as cartilage tissue engineering
- The hyaluronic acid hydrazide can also be used as an intermediate to synthesize other HA derivatives with various functional groups.
特点和优势
- Biocompatible and biodegradable
- Greater than 60% functionalized
- Tailorable for tethering additional functional groups or biochemical moieties
相关产品
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
G D Prestwich et al.
Journal of controlled release : official journal of the Controlled Release Society, 53(1-3), 93-103 (1998-09-19)
Controlled modification of the carboxylic acid moieties of hyaluronic acid with mono- and polyfunctional hydrazides leads to biochemical probes, biopolymers with altered physical and chemical properties, tethered drugs for controlled release, and crosslinked hydrogels as biocompatible scaffoldings for tissue engineering.
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