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Merck
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924474

Sigma-Aldrich

透明质酸

Low Viscosity, Low endotoxin

别名:

3D 生物打印, HA, 玻尿酸

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500 MG
$322.00

$322.00


国内现货,预计发货时间2025年4月23日详情


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500 MG
$322.00

About This Item

UNSPSC代码:
12352201
NACRES:
NA.23

$322.00


国内现货,预计发货时间2025年4月23日详情


获取大包装报价

质量水平

表单

(powder or chunk(s) or fibers)

杂质

<10 CFU/g Bioburden
<100 EU/g Endotoxin

颜色

white to off-white

适用性

conforms to structure for NMR

储存温度

2-8°C

一般描述

透明质酸(HA)是细胞外基质中由交替相间的D-葡萄糖醛酸和N-乙酰-D-氨基葡萄糖聚合而成的线性多糖。HA常用于化学改性制备共价交联的水凝胶。HA还可用于细胞表面受体CD44和RHAMM识别以及透明质酸酶催化降解。

应用

透明质酸在下列生物医药中的应用日渐增加:
  • 细胞迁移
  • 血管生成
  • 细胞活力
  • 细胞增殖

我们的低内毒素透明质酸同时经过内毒素(< 100 Eu/g)和微生物负荷(< 10 CFU/g)水平测试,方便用户选择适合的研究材料。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Xian Xu et al.
Soft matter, 8(12), 3280-3294 (2012-03-16)
Hyaluronic acid (HA) is one of nature's most versatile and fascinating macromolecules. Being an essential component of the natural extracellular matrix (ECM), HA plays an important role in a variety of biological processes. Inherently biocompatible, biodegradable and non-immunogenic, HA is
Federica Camin et al.
Journal of agricultural and food chemistry, 58(1), 570-577 (2009-12-17)
H, C, and O stable isotope ratios and the elemental profile of 267 olive oils and 314 surface waters collected from 8 European sites are presented and discussed. The aim of the study was to investigate if olive oils produced
Tracey J Brown
Current pharmaceutical biotechnology, 9(4), 253-260 (2008-08-12)
Despite advances in chemotherapeutic regimens, the treatment of metastatic cancer remains a challenge. A key problem with chemotherapy drugs is nonspecific drug distribution, resulting in low tumor concentrations and systemic toxicity. The holy grail of clinical cancer research has been
Kevin T Dicker et al.
Acta biomaterialia, 10(4), 1558-1570 (2013-12-24)
Hyaluronan (HA) is a linear polysaccharide with disaccharide repeats of d-glucuronic acid and N-acetyl-d-glucosamine. It is evolutionarily conserved and abundantly expressed in the extracellular matrix (ECM), on the cell surface and even inside cells. Being a simple polysaccharide, HA exhibits
Jason A Burdick et al.
Advanced materials (Deerfield Beach, Fla.), 23(12), H41-H56 (2011-03-12)
Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human body, is crucial for many cellular and tissue functions and has been in clinical use for over thirty years. When chemically modified, HA can be transformed into many

商品

Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. what MW range is the HA in this poduct?

    1 answer
    1. The molecular weight of this product is not determined. However, historical data suggests batches typically have a Mn (molecular number) around 20-40kDa.

      Helpful?

  4. How can this product best be reconstituted for surface coating TC substrates?

    1 answer
    1. Unfortunately, this product is not tested for solubility. However, according to the literature, Hyaluronic acid is soluble in water. Dissolve in cold water and shake slowly until the hyaluronic acid is dissolved completely. Please note this has not been validated internally.

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