928313

tBuBrettPhos Pd G3 ChemBeads

• 别名: tert-BuBrettPhos-Pd-G3, [(2-Di-tert-butylphosphino-3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate
• 经验公式（希尔记法）: C₄₄H₆₂NO₅PPdS
• CAS号: 1536473-72-9
• 分子量: 854.43
• MDL號碼: MFCD25976528
• 分類程式碼代碼: 12352101
• NACRES: NA.82

属性

• 形狀: solid
• 品質等級: 100
• 成份: ~ 5 wt.% loading of catalyst
• 反應適用性: reagent type: catalyst; reaction type: Cross Couplings
• SMILES 字串: [Pd+]c3c(cccc3)c4c(cccc4)N.P(C(C)(C)C)(C(C)(C)C)c1c(ccc(c1c2c(cc(cc2C(C)C)C(C)C)C(C)C)OC)OC.[S](=O)(=O)([O-])C
• InChI: 1S/C31H49O2P.C12H10N.CH4O3S.Pd/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;/h15-21H,1-14H3;1-6,8-9H,13H2;1H3,(H,2,3,4);/q;;;+1/p-1
• InChI 密鑰: GAQPAUHHECNHNS-UHFFFAOYSA-M

说明

一般說明

tBuBrettPhos Pd G3 is a third generation (G3) Buchwald precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. It is air-, moisture-, and thermally-stable and is highly soluble in a wide range of common organic solvents. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

For larger scale uses, product also available in powdered form (745979)

應用

tBuBrettPhos Pd G3 has been used as a precatalyst for the N-arylation of amino acid esters with aryl triflates under mild reaction conditions and minimal racemization of the amino acid ester. It may also be used to catalyze the conversion of aryl halides to phenols in the presence of benzaldoxime as a hydroxide surrogate.


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其他說明

High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads

Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation

ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H350i
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Carc. 1B Inhalation
• 儲存類別代碼: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• 水污染物質分類（WGK）: WGK 3