901210

Prop-2-yn-1-ylhydrazine hydrochloride

≥95%

• 别名: 2-Propynylhydrazine HCl, Clickable, nucleophilic hydrazine probe
• 经验公式（希尔记法）: C₃H₆N₂ · xHCl
• CAS号: 1187368-95-1
• 分子量: 70.09 (free base basis)
• MDL编号: MFCD29763172
• UNSPSC代码: 12352101

属性

• 方案: ≥95%
• 表单: solid
• 储存温度: 2-8°C

说明

应用

Useful synthetic building blocks for various chemical biology applications requiring a bioorthogonal alkyne. Ben Cravatt′s lab recently developed clickable, nucleophilic hydrazine probes for "reverse-polarity" activity-based protein profiling, or (RP)-ABPP. This propargyl hydrazine was used as an alkyl probe to capture protein-bound electrophiles in cells where the hydrazine acts as the nucleophile and alkyne enables protein enrichment and detection. Such methods facilitate discovery of protein modifcations that may not be predicted through typical protein sequence analyses.

901183 was used as a non-clickable competitor in profiling assays. To obtain greater coverage of high-reactivity targets, the aryl probe 901209 can be used in parallel.

其他说明

Chemoproteomic profiling and discovery of protein electrophiles in human cells

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable