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Merck

673927

Sigma-Aldrich

N-Boc-4-甲基-4-哌啶甲酸乙酯

97%

别名:

1-tert-Butoxycarbonyl-4-methylpiperidine-4-carboxylic acid ethyl ester, 4-Methyl-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester

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About This Item

经验公式(希尔记法):
C14H25NO4
分子量:
271.35
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

方案

97%

折射率

n20/D 1.4554

密度

1.0134 g/mL at 25 °C

SMILES字符串

CCOC(=O)C1(C)CCN(CC1)C(=O)OC(C)(C)C

InChI

1S/C14H25NO4/c1-6-18-11(16)14(5)7-9-15(10-8-14)12(17)19-13(2,3)4/h6-10H2,1-5H3

InChI key

ZQZVWDXMUCTNRI-UHFFFAOYSA-N

应用

将酯官能团替换为氨基官能团,为哌嗪基 CCR5 拮抗剂提供关键的结构单元。[1]
Reactant for synthesis of:
  • Dipeptidyl peptidase-4 inhibitor ABT-279
  • Building blocks for piperazine-based CCR5 antagonists

象形图

Skull and crossbonesCorrosion

警示用语:

Danger

危险分类

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

>230.0 °F

闪点(°C)

> 110 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Xiao-Hua Jiang et al.
Bioorganic & medicinal chemistry letters, 14(14), 3675-3678 (2004-06-19)
4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius rearrangement as a key step.

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